Results 81 to 90 of about 20,034 (267)

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, EarlyView.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source

Na+/Ca2 + Exchange and Pacemaker Activity of Interstitial Cells of Cajal

Frontiers in Physiology, 2020
Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical slow waves in gastrointestinal (GI) smooth muscles. Slow waves organize basic motor patterns, such as peristalsis and segmentation in the GI tract.
Haifeng Zheng, Bernard T. Drumm, Mei Hong Zhu, Yeming Xie, Kate E. O’Driscoll, Salah A. Baker, Brian A. Perrino, Sang Don Koh, Kenton M. Sanders   +8 more
doaj   +1 more source

Diabetic gastroenteropathy: Associations between gastrointestinal symptoms, motility, and extraintestinal autonomic measures

Neurogastroenterology &Motility, EarlyView.
We found no associations between gastrointestinal and extraintestinal measures of diabetic autonomic neuropathy. Nonetheless, gastrointestinal symptoms increased with the severity of cardiovascular autonomic neuropathy and were associated with gastrointestinal measures.
Ditte S. Kornum, Christina Brock, Tina Okdahl, Davide Bertoli, Huda Kufaishi, Anne‐Marie Wegeberg, Katrine L. Høyer, Esben B. Mark, Birgitte Brock, Christian S. Hansen, Filip K. Knop, Asbjørn M. Drewes, Klaus Krogh   +12 more
wiley   +1 more source

Clinical‐histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium [PDF]

, 2012
Background  Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium.
Abell, Bytzer, Camilleri, Cassilly, Chen, Choi, Choi, Choi, Costa, Farrugia, Forster, Gangula, Grover, Harberson, He, Holness, Horny, Iwasaki, Jung, Kashyap, Khazen, Koch, Lin, Mashimo, Miller, Ordog, Parkman, Parkman, Pasricha, Plourde, Rentz, Samsom, Sarnelli, Shah, Sokol, Spangeus, Tack, Takahashi, Vittal, Wang, Wang, Zarate   +41 more
core   +2 more sources

Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine

Neurogastroenterology &Motility, EarlyView.
Mechanosensitivity of the smooth muscle induces a positive‐feedback loop that spontaneously generates pressure gradients across gut segments and stabilizes initially applied pressure gradients. It can act jointly or compete with the pressure gradient induced by directional peristaltic waves.
Richard J. Amedzrovi Agbesi, Lucas Chassatte, Nicolas R. Chevalier   +2 more
wiley   +1 more source

Pulse-Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs. [PDF]

, 2015
BackgroundNonresectable mast cell tumors (MCT) in dogs remain a therapeutic challenge, and investigation of novel combination therapies is warranted. Intermittent administration of tyrosine kinase inhibitors (TKI) combined with cytotoxic chemotherapy may
Avery, AC, Axiak-Bechtel, SM, Burton, JH, Clifford, CA, Thamm, DH, Vail, DM, Venable, RO, Williams, LE   +7 more
core   +1 more source

Magnetic Resonance Imaging of Gastric Motility in Conscious Rats

Neurogastroenterology &Motility, EarlyView.
By training rats to remain awake inside an MRI scanner, we can now noninvasively scan their gastrointestinal tracts without using anesthesia. This allows us to assess gastric motility and emptying in conscious rats without the various confounding effects that anesthesia might cause.
Xiaokai Wang, Fatimah Alkaabi, Ashley Cornett, Minkyu Choi, Ulrich M. Scheven, Madeleine R. Di Natale, John B. Furness, Zhongming Liu   +7 more
wiley   +1 more source

Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal. [PDF]

, 2011
BACKGROUND: We previously identified eight known and novel genes differentially expressed in the small intestines of wild type and W/WV mice, which have greatly reduced populations of the interstitial cells of Cajal, that are responsible for the ...
Caldas, Carlos, Daigo, Yataro, Fujino, Masayuki A, Ponder, Bruce AJ, Sanders, Kenton M, Takayama, Ichiro, Ward, Sean M   +6 more
core  

Reduction of Interstitial Cells of Cajal in Esophageal Atresia

Journal of Pediatric Gastroenterology and Nutrition, 2010
ABSTRACTObjectives:Postrepair esophageal dysmotility and gastroesophageal reflux are well‐known consequences in patients with congenital esophageal atresia (EA) with or without distal tracheoesophageal fistula (TEF). The interstitial cells of Cajal (ICC), considered the intestinal pacemaker, are altered in congenital diseases with abnormal peristalsis,
MIDRIO P, ALAGGIO, RITA, STROJNA A, GAMBA, PIERGIORGIO, GIACOMELLI L, PIZZI S, FAUSSONE PELLEGRINI M. S.   +6 more
openaire   +4 more sources

Relationship Between Intragastric Meal Distribution, Gastric Emptying, and Gastric Neuromuscular Dysfunction in Chronic Gastroduodenal Disorders

Neurogastroenterology &Motility, EarlyView.
Multimodal physiological testing using gastric emptying scintigraphy with intragastric meal distribution and body surface gastric mapping showed proximal retention of food correlated with delayed emptying and neuromuscular spectral abnormalities (abnormal slow wave frequencies or rhythms) and delayed motility responses on BSGM.
Chris Varghese, Armen A. Gharibans, Daphne Foong, Gabriel Schamberg, Stefan Calder, Vincent Ho, Reena Anand, Christopher N. Andrews, Alan H. Maurer, Thomas Abell, Henry P. Parkman, Greg O'Grady   +11 more
wiley   +1 more source