Results 21 to 30 of about 10,940 (177)

Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis

Frontiers in Systems Neuroscience, 2022
Imatinib mesylate is a tyrosine kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR)-α, -β, stem cell factor receptor (c-KIT), and BCR-ABL.
Megan Perkins, Beatrice M. Girard, Susan E. Campbell, Grant W. Hennig, Margaret A. Vizzard   +4 more
doaj   +1 more source

Notch1 Signaling Contributes to Mechanical Allodynia Associated with Cyclophosphamide-Induced Cystitis by Promoting Microglia Activation and Neuroinflammation

Mediators of Inflammation, 2021
Aims. Notch1 signaling regulates microglia activation, which promotes neuroinflammation. Neuroinflammation plays an essential role in various kinds of pain sensation, including bladder-related pain in bladder pain syndrome/interstitial cystitis (BPS/IC).
Jialiang Chen, Honglu Ding, Bolong Liu, Xiangfu Zhou, Xin Zhou, Zhijun Lin, Fei Yang, Hailun Zhan, Hengjun Xiao   +8 more
doaj   +1 more source

Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing

Frontiers in Immunology
BackgroundSeveral observational studies have indicated an association between interstitial cystitis and the composition of the gut microbiota; however, the causality and underlying mechanisms remain unclear.
Chaowei Fu, Yu Zhao, Xiang Zhou, Jing Lv, Shengkai Jin, Yuhua Zhou, Fengping Liu, Ninghan Feng, Ninghan Feng   +8 more
doaj   +1 more source

Personal cell therapy for interstitial cystitis with autologous stromal vascular fraction stem cells

Therapeutic Advances in Urology, 2019
Background: The objective of this study was to evaluate whether autologous stem-cell-based therapy may mitigate the symptoms of interstitial cystitis. Methods: Stromal vascular fraction (SVF) rich in stem cells and derived from autologous adipose tissue ...
Elliot B. Lander, Mark H. Berman, Jackie R. See   +2 more
doaj   +1 more source

Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome

Cellular Physiology and Biochemistry, 2016
Background/Aims: To assess the efficacy of intravesical hyaluronic acid (HA) and HA/chondroitin sulfate (CS) instillation in patients with interstitial cystitis/painful bladder syndrome by systematic review and meta-analysis.
Jung-Soo Pyo, Won Jin Cho
doaj   +1 more source

Imatinib Mesylate Reduces Voiding Frequency in Female Mice With Acute Cyclophosphamide-Induced Cystitis

Frontiers in Systems Neuroscience, 2022
Lamina propria interstitial cells that express the tyrosine kinase receptor, platelet-derived growth factor receptor alpha (PDGFRα) may play a role in urinary sensory signaling.
Megan E. Perkins, Beatrice M. Girard, Susan E. Campbell, Margaret A. Vizzard   +3 more
doaj   +1 more source

Evaluation of Patients with Painful Bladder Syndrome/Interstitial Cystitis

The Scientific World Journal, 2005
This review looks into the evaluation of patients with interstitial cystitis (IC). Interstitial cystitis is not easy to define. There is a lot of activity in this domain and a great international effort is made to get to a generally accepted definition ...
Jean Jacques Wyndaele
doaj   +1 more source

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Hysteroscopy metroplasty for partial septate uterus: Just a matter of infertility?

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The primary objective of this study is to assess the impact of hysteroscopic metroplasty on symptom relief, including dysmenorrhea, dyspareunia, and menstrual blood flow in women with partial uterine septa (U2a class). Additionally, the study aims to investigate potential correlations between clinical and ultrasonographic ...
Alessandro Arena, Agnese Virgilio, Camilla Franceschini, Erika Bettiol, Pierandrea De Benedetti, Roberto Sardina, Giulia Cincotta, Eugenia Mantovani, Renato Seracchioli, Paolo Casadio   +9 more
wiley   +1 more source

A Novel Use of Cyclobenzaprine and Hyoscyamine (BLAVACARE _TM) Impregnated Vaginal Suppositories for the Symptomatic Treatment of Interstitial Cystitis, Bladder Spasms, and Painful Bladder Syndrome

Uro, 2021
Interstitial Cystitis and Painful Bladder Syndrome are chronic conditions that are associated with urinary frequency, urgency, pain, and nocturia. The etiology of IC/PBS is not clearly understood, therefore diagnosis and treatment can be challenging.
Cheau Williams, Kirby Smith, Woodwin Weeks, Arian Baker, Stephen Yarbrough, Samantha Leggio, Ummar Jamal   +6 more
doaj   +1 more source