Results 151 to 160 of about 765,049 (358)

Utility of Transbronchial vs Surgical Lung Biopsy in the Diagnosis of Suspected Fibrotic Interstitial Lung Disease [PDF]

, 2016
Jamie S. Sheth, John A. Belperio, Michael C. Fishbein, Ella A. Kazerooni, Amir Lagstein, Susan Murray, Jeff L. Myers, Richard H. Simon, Thomas H. Sisson, Baskaran Sundaram, Eric S. White, Meng Xia, David A. Zisman, Kevin R. Flaherty   +13 more
openalex   +1 more source

Critical Care Ultrasonography and Its Application for COVID-19 [PDF]

, 2020
Ultrasound has developed as an invaluable tool in diagnosis and proper management in the intensive care unit (ICU). Application of critical care ultrasonography is quite distinct from the routine comprehensive diagnostic ultrasound exam, because the ...
Chong, MD, Weelic, Hai, MD, Yang, Liu, MD, Ji-Bin, Liu, MD, Xi, Ma, MD, Bin   +4 more
core   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Performance of Candidate Serum Biomarkers for Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis & Rheumatology, 2019
Interstitial lung disease (ILD) in systemic sclerosis (SSc) runs a highly variable course, and prediction tools are highly desired. The aim of this study was to assess the diagnostic and prognostic performance of 4 candidate serum biomarkers for SSc ...
M. Elhai, A. Hoffmann-Vold, J. Avouac, S. Pezet, A. Cauvet, A. Leblond, H. Fretheim, T. Garen, M. Kuwana, Ø. Molberg, Y. Allanore   +10 more
semanticscholar   +1 more source

Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles

Advanced Science, EarlyView.
Norepinephrine/α2B‐adrenoceptor axis promotes the secretion of Notch2 intracellular domain (N2ICD)‐enriched extracellular vesicles (EVs) from macrophages. These EVs deliver N2ICD into fibroblasts, thereby inducing their activation. Deletion of Notch2 or α2B‐AR in macrophages disrupts N2ICD‐enriched EV formation and alleviates kidney fibrosis in mice ...
Huiwen Ren, Yayan Hou, Chengsen Mu, Yinghong Zheng, Yuanyang Wang, Shumin Guo, Lu Wang, Wenlong Shang, Zhuming Yin, Cheng Dong, Yongsheng Chang, Bin Zhou, Renjie Chai, Ying Yu, Yujun Shen   +14 more
wiley   +1 more source

South–West of England’s Experience of the Safety and Tolerability Pirfenidone and Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)

Frontiers in Pharmacology, 2018
Purpose: Pirfenidone and nintedanib are two novel antifibrotic agents licensed for the treatment IPF. Prior to being approved for use in England for patients with FVC >50% and <80%, these were made available for all IPF patients under the Mild ...
Shaney L. Barratt, Sarah Mulholland, Khaled Al Jbour, Henry Steer, Markus Gutsche, Noeleen Foley, Rajiv Srivastava, Charles Sharp, Huzaifa I. Adamali   +8 more
doaj   +1 more source

AB0607 MYOSITIS-RELATED INTERSTITIAL LUNG DISEASES: CLINICAL FEATURES, BIOMARKERS AND AUTOANTIBODIES IN LATINOAMERICAN PATIENTS [PDF]

, 2020
S. M. Sánchez Romo, Guiomar Mendieta, Miguel Ángel Villarreal‐Alarcón, I. D. J. Hernandez-Galarza, D. Á. Galarza-Delgado   +4 more
openalex   +1 more source

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

Advanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma, Yang Chen, Qinfan Yao, Yuxi Wang, Nan Ouyang, Fei Han, Guzong Wang, Meifang Wang, Yuan Yuan, Jianghua Chen, Jianzhen Shan, Dajin Chen   +11 more
wiley   +1 more source

Occupational exposures in sarcoidosis: a protocol for a multicentre regional case–control study in the UK

BMJ Open Respiratory Research
Background Sarcoidosis is a multisystem granulomatous disease of unclear cause. An environmental trigger in a genetically susceptible individual resulting in immune dysregulation is suspected.
Alice Margaret Turner, Sherwood Burge, Gareth I Walters, Christopher C Huntley   +3 more
doaj   +1 more source

Incidence, Timing, and Setting of Palliative Care Referrals in Patients with Interstitial Lung Disease [PDF]

, 2020
Rebecca A. Gersten, Tian Wu, Sam Mathai, Sonye K. Danoff   +3 more
openalex   +1 more source