Results 161 to 170 of about 774,384 (405)

Home oxygen for children: who, how and when? [PDF]

, 2005
A review of the specific requirements of home oxygen therapy in children which attempts to offer guidance to clinicians and service ...
Balfour-Lynn, I.M., Primhak, R.A., Shaw, B.N.J.   +2 more
core   +2 more sources

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease

Arthritis Research & Therapy, 2019
BackgroundBiomarkers have been actively investigated to supplement functional and imaging modalities to predict the severity, therapeutic responsiveness, and progression of connective tissue disease-associated interstitial lung disease (CTD-ILD).
J. Lee, E. Lee, Y. Ha, E. Kang, Y. Lee, Y. Song   +5 more
semanticscholar   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Telomere length and genetic variant associations with interstitial lung disease progression and survival

European Respiratory Journal, 2019
Leukocyte telomere length (LTL), MUC5B rs35705950 and TOLLIP rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF). In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival ...
C. Newton, J. Oldham, B. Ley, V. Anand, A. Adegunsoye, Gabrielle Y. Liu, Kiran Batra, J. Torrealba, J. Kozlitina, C. Glazer, M. Strek, P. Wolters, I. Noth, C. Garcia   +13 more
semanticscholar   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

A first look at the reliability, validity and responsiveness of L-PF-35 dyspnea domain scores in fibrotic hypersensitivity pneumonitis

BMC Pulmonary Medicine
Background Dyspnea impairs quality of life (QOL) in patients with fibrotic hypersensitivity pneumonitis (FHP). The Living with Pulmonary Fibrosis questionnaire (L-PF) assesses symptoms, their impacts and PF-related QOL in patients with any form of PF ...
Jeffrey J. Swigris, Kerri Aronson, Evans R. Fernández Pérez   +2 more
doaj   +1 more source

RAPIDLY PROGRESSIVE INTERSTITIAL LUNG DISEASE IN DERMATOMYOSITIS PATIENT SUCCESSFULLY TREATED WITH TRIPLE THERAPY

, 2021
Bruno Bordallo Corrêa, Julio Cezar Borges, Maria Isabel Dutra Souto, Blanca Elena Ríos Gomes Bica, Bruno Bordallo Corrêa, HANY KELLY ARAUJO CRUZ, Marcus Vinicius de Jesus da Silva, Julia Yoneshigue Laranja de Oliveira, Lizeth Chaparro Del Portillo, Luiza Catharina Brusasco Grandini   +9 more
openalex   +1 more source

Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2019
Interleukin (IL)-17 is a T helper 17 cytokine implicated in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). Although IL-17A has a well-established role in murine pulmonary fibrosis models, its role in the tissue ...
Jie Zhang, Dan Wang, Lei Wang, Shaohua Wang, A. Roden, Hao Zhao, Xiujuan Li, Xiujuan Li, Y. Prakash, E. Matteson, D. Tschumperlin, R. Vassallo   +11 more
semanticscholar   +1 more source