Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Incorrectly corrected? QT interval analysis in rats and mice. [PDF]
Front Physiol, 2022 Mulla W, Murninkas M, Levi O, Etzion Y.
europepmc +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
THE METHOD OF RANKING EFFECTIVE PROJECT SOLUTIONS IN CONDITIONS OF INCOMPLETE CERTAINTY
Сучасні інформаційні системиThe subject of research in the article is the process of ranking options in support systems for project decision-making under conditions of incomplete certainty.
Volodymyr Bezkorovainyi +3 more
doaj +1 more source
Implementation and verification of global optimization benchmark problems
Open Engineering, 2017 The paper considers the implementation and verification of a test suite containing 150 benchmarks for global deterministic box-constrained optimization. A C++ library for describing standard mathematical expressions was developed for this purpose.
Posypkin Mikhail, Usov Alexander
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Surrogate-Model-Based Interval Analysis of Spherical Conformal Array Antenna with Power Pattern Tolerance. [PDF]
Sensors (Basel), 2022 Ding G, Li P, Rocca P, Chang J, Xu W.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Quantifying Uncertainty in State Estimation: The MoK-FoBS Method via Interval Analysis
IEEE AccessThe Bayesian framework is conventionally adopted in power system static state estimation (SSE) to quantify uncertainty via probability density functions (PDFs). However, the reliability of such PDFs is frequently undermined by the complex nature of noise
Yuting Chen, Ning Zhou, Ziang Zhang
doaj +1 more source
Opioid Overdose Risk Following Hospital Discharge Among Individuals Prescribed Long-Term Opioid Therapy: a Risk Interval Analysis. [PDF]
J Gen Intern Med, 2023 Lyden JR +4 more
europepmc +1 more source