Results 61 to 70 of about 1,743,511 (277)

Nonparametric survival analysis of epidemic data

, 2011
This paper develops nonparametric methods for the survival analysis of epidemic data based on contact intervals. The contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j, where
Aalen, Aalen, Altshuler, Becker, Becker, Carcione, Cauchemez, Cox, Dempster, Donnelly, Ferguson, Ferguson, Fine, France, Fraser, Kalbfleisch, Kaplan, Kenah, Kenah, Lee, Lipsitch, McBryde, Mills, Morgan, Müller, Nelson, Rampey, Rhodes, Roberts, Sinha, Sugimoto, Svensson, Van der Vaart, Wallinga, Wallinga, Watts, Wegman, White, Yang   +38 more
core   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Simultaneous Confidence Interval Estimation

The Annals of Mathematical Statistics, 1953
The work of Neyman on confidence limits and of Fisher on fiducial limits is well known. However, in most applications the interval or limits for only a single parameter or a single function of the parameters has been considered. Recently Scheffe [2] and Tukey [3] have considered special cases of what may be called problems of simultaneous estimation ...
Roy, S. N., Bose, R. C.
openaire   +2 more sources

Set identification with Tobin regressors [PDF]

We give semiparametric identification and estimation results for econometric models with a regressor that is endogenous, bound censored and selected,called a Tobin regressor. First, we show that true parameter value is set identified and characterize the
Roberto Rigobon, Thomas Stoker, Victor Chernozhukov   +2 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Confidence intervals for partially identified parameters [PDF]

In the last decade a growing body of research has studied inference on partially identified parameters (e.g., Manski, 1990, 2003). In many cases where the parameter of interest is realvalued, the identification region is an interval whose lower and upper
Charles F. Manski, Guido Imbens
core  

Modelling primary health care use: a panel zero inflated interval regression approach [PDF]

, 2012
We introduce the (panel) zero-inflated interval regression (ZIIR) model, to investigate GP visits using individual-level data from the British Household Panel Survey.
Brown, S., Harris, M.N., Roberts, J., Taylor, K.   +3 more
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source