Results 121 to 130 of about 226,666 (311)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

m-Polar interval-valued fuzzy hypergraphs and its application in decision-making problems

open access: yesHeliyon
This study introduces the novel concept of m-polar interval-valued fuzzy hypergraph (m-PIVFHG), an advancement that combines the strengths of fuzzy theory and hypergraph models to improve decision-making processes.
Sanchari Bera   +3 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Interval graph limits

open access: yes, 2011
We work out the graph limit theory for dense interval graphs. The theory developed departs from the usual description of a graph limit as a symmetric function W (x, y) on the unit square, with x and y uniform on the interval (0, 1).
Susan Holmes   +2 more
core  

Interval graphs and proper interval graphs in Fuzzy and Neutrosophic Graphs

open access: yesInformation Sciences with Applications
Interval graphs represent vertices as intervals on the real line, with edges denoting overlapping intervals, while proper interval graphs prevent one interval from being fully contained within another. This paper explores interval and proper interval graphs within the frameworks of fuzzy, neutrosophic, and Turiyam Neutrosophic graphs.
Takaaki Fujita, Florentin Smarandache
openaire   +2 more sources

On the One Dimensional Poisson Random Geometric Graph

open access: yesJournal of Probability and Statistics, 2011
Given a Poisson process on a bounded interval, its random geometric graph is the graph whose vertices are the points of the Poisson process, and edges exist between two points if and only if their distance is less than a fixed given threshold. We compute
L. Decreusefond, E. Ferraz
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

Removing Twins in Graphs to Break Symmetries

open access: yesMathematics, 2019
Determining vertex subsets are known tools to provide information about automorphism groups of graphs and, consequently about symmetries of graphs. In this paper, we provide both lower and upper bounds of the minimum size of such vertex subsets, called ...
Antonio González, María Luz Puertas
doaj   +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

open access: yesArthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk   +16 more
wiley   +1 more source

A Note on the Interval Function of a Disconnected Graph

open access: yesDiscussiones Mathematicae Graph Theory, 2018
In this note we extend the Mulder-Nebeský characterization of the interval function of a connected graph to the disconnected case. One axiom needs to be adapted, but also a new axiom is needed in addition.
Changat Manoj   +3 more
doaj   +1 more source

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