Results 101 to 110 of about 3,565,508 (299)
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ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
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ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Axiomatic characterization of the interval function of partial cubes and partial Hamming graphs
Interval function of a graph is a well-known notion in metric graph theory and the axiomatic characterization using a set of first order axioms of different graph classes is an interesting problem in this area.
Jeny Jacob +4 more
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ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro +14 more
wiley +1 more source
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
m-Polar interval-valued fuzzy hypergraphs and its application in decision-making problems
This study introduces the novel concept of m-polar interval-valued fuzzy hypergraph (m-PIVFHG), an advancement that combines the strengths of fuzzy theory and hypergraph models to improve decision-making processes.
Sanchari Bera +3 more
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Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad +22 more
wiley +1 more source
A characterization of the Total Graph of Interval Graphs and Proper Interval Graphs
An asteroidal triple is a stable set of three vertices such that each pair is connected by a path avoiding the neighbourhood of the third vertex. Let G be a graph with vertex set V (G) and edge set E(G), the total graph T(G) of G has vertex set V (G)∪E(G) and two vertices in T(G) are adjacent if and only if they are adjacent or incident in G.
Athul T B, G Suresh Singh
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