Results 81 to 90 of about 842,486 (276)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The order difference interval graph of a group [PDF]

open access: yesTransactions on Combinatorics, 2012
In this paper we introduce the concept of order difference interval graph ¡ODI (G) of a group G. It is a graph ¡ODI (G) with V (¡ODI (G)) = G and two vertices a and b are adjacent in ¡ODI (G) if and only if o(b) − o(a) ∈ [o(a), o(b)].
P. Balakrishnan, R. Kala
doaj  

A Reduction of the Graph Reconstruction Conjecture

open access: yesDiscussiones Mathematicae Graph Theory, 2014
A graph is said to be reconstructible if it is determined up to isomor- phism from the collection of all its one-vertex deleted unlabeled subgraphs. Reconstruction Conjecture (RC) asserts that all graphs on at least three vertices are reconstructible. In
Monikandan S., Balakumar J.
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Interval k-Graphs and Orders [PDF]

open access: yesOrder, 2017
An interval $k$-graph is the intersection graph of a family $\mathcal{I}$ of intervals of the real line partitioned into at most $k$ classes with vertices adjacent if and only if their corresponding intervals intersect and belong to different classes.
Brown, David E.   +2 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Interval graphs and interval orders

open access: yesDiscrete Mathematics, 1985
This paper investigates the connection between interval graphs and interval orders, with special attention to the family of interval orders that agree with or provide representations of an interval graph. Relationships between interval graphs and interval orders that concern the number of lengths required for interval representations and bounds on ...
openaire   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

- and -labeling problems on interval graphs

open access: yesAKCE International Journal of Graphs and Combinatorics, 2017
For a given graph , the - and -labeling problems assign the labels to the vertices of . Let be the set of non-negative integers. An - and -labeling of a graph is a function such that , for respectively, where represents the distance (minimum number of ...
Sk Amanathulla, Madhumangal Pal
doaj   +1 more source

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