Results 61 to 70 of about 3,565,508 (299)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Interval Valued Intuitionistic Fuzzy Line Graphs

BMC Research Notes, 2022
Objectives In the field of graph theory, an intuitionistic fuzzy set becomes a useful tool to handle problems related to uncertainty and impreciseness. We introduced the interval-valued intuitionistic fuzzy line graphs (IVIFLG) and explored the results ...
V. N. Srinivasa Rao Repalle, Keneni Abera Tola, Mamo Abebe Ashebo   +2 more
doaj   +1 more source

New Concepts of Vertex Covering in Cubic Graphs with Its Applications

Mathematics, 2022
Graphs serve as one of the main tools for the mathematical modeling of various human problems. Fuzzy graphs have the ability to solve uncertain and ambiguous problems.
Huiqin Jiang, Ali Asghar Talebi, Zehui Shao, Seyed Hossein Sadati, Hossein Rashmanlou   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Closed graphs are proper interval graphs

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2014
Let G be a connected simple graph. We prove that G is a closed graph if and only if G is a proper interval graph. As a consequence we obtain that there exist linear-time algorithms for closed graph recognition.
Crupi Marilena, Rinaldo Giancarlo
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

The order difference interval graph of a group [PDF]

Transactions on Combinatorics, 2012
In this paper we introduce the concept of order difference interval graph ¡ODI (G) of a group G. It is a graph ¡ODI (G) with V (¡ODI (G)) = G and two vertices a and b are adjacent in ¡ODI (G) if and only if o(b) − o(a) ∈ [o(a), o(b)].
P. Balakrishnan, R. Kala
doaj  

A Reduction of the Graph Reconstruction Conjecture

Discussiones Mathematicae Graph Theory, 2014
A graph is said to be reconstructible if it is determined up to isomor- phism from the collection of all its one-vertex deleted unlabeled subgraphs. Reconstruction Conjecture (RC) asserts that all graphs on at least three vertices are reconstructible. In
Monikandan S., Balakumar J.
doaj   +1 more source