Results 31 to 40 of about 153,098 (217)
Pediatric Blood &Cancer, EarlyView.ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz +7 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The niche graphs of interval orders
Discussiones Mathematicae Graph Theory, 2014 The niche graph of a digraph D is the (simple undirected) graph which has the same vertex set as D and has an edge between two distinct vertices x and y if and only if N+D(x) ∩ N+D(y) ≠ ∅ or N−D(x) ∩ N−D(y) ≠ ∅, where N+D(x) (resp.
Park Jeongmi, Sano Yoshio
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On the Representation of a PI-Graph
Trends in Computational and Applied Mathematics, 2007 Consider two parallel lines (denoted r1 and r2). A graph is a PI graph (Point-Interval graph) if it is an intersection graph of a family F of triangles between r1 and r2 such that each triangle has an interval with two endpoints on r1 and a vertex (a ...
S.M. Almeida, C.P. de Mello, A. Gomide
doaj +1 more source
Equivalence of the filament and overlap graphs of subtrees of limited trees [PDF]
Discrete Mathematics & Theoretical Computer Science, 2017 The overlap graphs of subtrees of a tree are equivalent to subtree filament graphs, the overlap graphs of subtrees of a star are cocomparability graphs, and the overlap graphs of subtrees of a caterpillar are interval filament graphs.
Jessica Enright, Lorna Stewart
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source