Results 51 to 60 of about 1,503,165 (299)

Simultaneous Interval Graphs [PDF]

open access: yes, 2010
In a recent paper, we introduced the simultaneous representation problem (defined for any graph class C) and studied the problem for chordal, comparability and permutation graphs. For interval graphs, the problem is defined as follows. Two interval graphs G_1 and G_2, sharing some vertices I (and the corresponding induced edges), are said to be ...
Krishnam Raju Jampani, Anna Lubiw
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The niche graphs of interval orders

open access: yesDiscussiones Mathematicae Graph Theory, 2014
The niche graph of a digraph D is the (simple undirected) graph which has the same vertex set as D and has an edge between two distinct vertices x and y if and only if N+D(x) ∩ N+D(y) ≠ ∅ or N−D(x) ∩ N−D(y) ≠ ∅, where N+D(x) (resp.
Park Jeongmi, Sano Yoshio
doaj   +1 more source

Uniquely orderable interval graphs

open access: yes, 2022
Interval graphs and interval orders are deeply linked. In fact, edges of an interval graphs represent the incomparability relation of an interval order, and in general, of different interval orders.
Fiori-Carones, Marta, Marcone, Alberto
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Interval Graphs [PDF]

open access: yes, 2016
We examine the problem of counting interval graphs. We answer the question posed by Hanlon, of whether the formal power series generating function of the number of interval graphs on n vertices has a positive radius of convergence.
Yang, Joyce C
core   +1 more source

Approximation hardness of optimization problems in intersection graphs of d-dimensional boxes [PDF]

open access: yes, 2005
The Maximum Independent Set problem in d-box graphs, i.e., in the intersection graphs of axis-parallel rectangles in R d , is a challenge open problem. For any fixed d ≥ 2 the problem is NP-hard and no approximation algorithm with ratio o(log d−1 n) is ...
Chlebikova, Janka   +5 more
core  

Counting interval graphs

open access: yes, 1982
In this paper we enumerate interval graphs (up to isomorphism) along with labelled interval graphs, identity interval graphs, transitive interval graphs and various sorts of unit interval graphs. The enumeration makes use of a structural decomposition of
Phil Hanlon
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

On the Representation of a PI-Graph

open access: yesTrends in Computational and Applied Mathematics, 2007
Consider two parallel lines (denoted r1 and r2). A graph is a PI graph (Point-Interval graph) if it is an intersection graph of a family F of triangles between r1 and r2 such that each triangle has an interval with two endpoints on r1 and a vertex (a ...
S.M. Almeida, C.P. de Mello, A. Gomide
doaj   +1 more source

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