Results 61 to 70 of about 588,772 (275)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

On $[1,2]$-Domination in Interval and Circle Graphs [PDF]

Discrete Mathematics & Theoretical Computer Science
A subset $S$ of vertices in a graph $G=(V, E)$ is a Dominating Set if each vertex in $V(G)\setminus S$ is adjacent to at least one vertex in $S$. Chellali et al.
Mohsen Alambardar Meybodi, Abolfazl Poureidi   +1 more
doaj   +1 more source

Algorithms for optimal min hop and foremost paths in interval temporal graphs

Applied Network Science, 2022
Path problems are fundamental to the study of graphs. Temporal graphs are graphs in which the edges connecting the vertices change with time. Min hop paths problem in a temporal graph is the problem of finding time respecting paths from source vertex to ...
Anuj Jain, Sartaj K. Sahni
doaj   +1 more source

Interval minors of complete bipartite graphs [PDF]

, 2014
Interval minors of bipartite graphs were recently introduced by Jacob Fox in the study of Stanley-Wilf limits. We investigate the maximum number of edges in $K_{r,s}$-interval minor free bipartite graphs. We determine exact values when $r=2$ and describe
Mohar, Bojan, Rafiey, Arash, Tayfeh-Rezaie, Behruz, Wu, Hehui   +3 more
core  

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

A Novel Study of Graphs Based on m-Polar Cubic Structures

Journal of Function Spaces, 2022
By combining the notions of interval-valued m-polar fuzzy graphs and m-polar fuzzy graphs, the notion of m-polar cubic graphs is first introduced. Then, the degree of a vertex in m-polar cubic graphs and complete m-polar cubic graphs is defined.
G. Muhiuddin, A. M. Alanazi, A. Mahboob, A. H. Alkhaldi, Wejdan Alatwai   +4 more
doaj   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

The upper chromatic number of quasi-interval co-hypergraphs

Le Matematiche, 1997
We investigate the structural and colouring properties of clique hyper-graphs of interval graphs called the quasi-interval hypergraphs. We find the conditions when they are interval hypergraphs. The upper chromatic number for the clique co-hypergraphs of
Violeta Prisakaru
doaj  

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

On the on-line coloring of unit interval graphs with proper interval representation [PDF]

Discrete Mathematics & Theoretical Computer Science
We define the problem as a two-player game between Algorithm and Builder. The game is played in rounds. Each round, Builder presents an interval that is neither contained in nor contains any previously presented interval.
Israel R. Curbelo, Hannah R. Malko
doaj   +1 more source