Results 121 to 130 of about 314,087 (295)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

An Ultra-Wide Swath Synthetic Aperture Radar Imaging System via Chaotic Frequency Modulation Signals and a Random Pulse Repetition Interval Variation Strategy

Remote Sensing
Ultra-wide swath synthetic aperture radar (SAR) systems are of great significance for applications such as terrain measurement and ocean monitoring. In conventional SAR systems, targets echo from the near-range and far-range of an observed swath mutually
Wenjiao Chen, Jiwen Geng, Yufeng Guo, Li Zhang   +3 more
doaj   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Do All Fast Radio Bursts Repeat? Constraints from CHIME/FRB Far Sidelobe FRBs

The Astrophysical Journal
We report 10 fast radio bursts (FRBs) detected in the far sidelobe region (i.e., ≥5° off-meridian) of the Canadian Hydrogen Intensity Mapping Experiment (CHIME) from August 28 2018 to August 31 2021. We localize the bursts by fitting their spectra with a
Hsiu-Hsien Lin, Paul Scholz, Cherry Ng, Ue-Li Pen, Mohit Bhardwaj, Pragya Chawla, Alice P. Curtin, Dongzi Li, Laura Newburgh, Alex Reda, Ketan R. Sand, Shriharsh P. Tendulkar, Bridget Andersen, Kevin Bandura, Charanjot Brar, Tomas Cassanelli, Amanda M. Cook, Matt Dobbs, Fengqiu Adam Dong, Gwendolyn Eadie, Emmanuel Fonseca, B. M. Gaensler, Utkarsh Giri, Antonio Herrera-Martin, Alex S. Hill, Jane Kaczmarek, Joseph Kania, Victoria Kaspi, Kholoud Khairy, Adam E. Lanman, Calvin Leung, Kiyoshi W. Masui, Juan Mena-Parra, Bradley Ward Meyers, Daniele Michilli, Nikola Milutinovic, Anna Ordog, Aaron B. Pearlman, Ziggy Pleunis, Masoud Rafiei-Ravandi, Mubdi Rahman, Scott Ransom, Pranav Sanghavi, Kaitlyn Shin, Kendrick Smith, Ingrid Stairs, David C Stenning, Keith Vanderlinde, Dallas Wulf   +48 more
doaj   +1 more source

As Time Goes By: Event File Decay Does Not Unleash Inhibition of Return

Journal of Cognition
Inhibition of return (IOR) refers to a location repetition cost typically observed when signaling the detection of or localizing sequentially presented stimuli repeating or changing their location.
Lars-Michael Schöpper, Christian Frings
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Novel Method of Unambiguous Moving Target Detection in Pulse-Doppler Radar with Random Pulse Repetition Interval

Leida xuebao, 2012
Blind zones and ambiguities in range and velocity measurement are two important issues in traditional pulse-Doppler radar. By generating random deviations with respect to a mean Pulse Repetition Interval (PRI), this paper proposes a novel algorithm of ...
Liu Zhen, Wei Xi-zhang, Li Xiang
doaj