Results 51 to 60 of about 96,590 (303)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Eyewitness accuracy and retrieval effort: Effects of time and repetition.

open access: yesPLoS ONE, 2022
An important task for the law enforcement is to assess the accuracy of eyewitness testimonies. Recent research show that indicators of effortful memory retrieval, such as pausing and hedging (e.g. "I think", "maybe"), are more common in incorrect recall.
Philip U Gustafsson   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Delineating the Role of Inter-Repetition Interval in the Relationship between Maximum Repetitions to Failure or Repetitions in Reserve and Movement Velocity

open access: yesSports Health: A Multidisciplinary Approach
Background: Maximum repetitions to failure (RTF) and repetitions in reserve (RIR) can be estimated through fastest mean velocity (MV fastest ) and mean velocity (MV), respectively.
Carlos Martínez-Rubio   +4 more
openaire   +3 more sources

Effect of rest interval length on repeated 1 repetition maximum back squats.

open access: yes, 2003
To examine the effects of different rest intervals on the repeatability of 1 repetition maximum (IRM) efforts in the free-weight back squat exercise, 17 weight-trained men served as subjects (mean age 22.0 years).
MARVIN M. MCKNIGHT   +9 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Time-Based Transition Expectancy in Task Switching: Do We Need to Know the Task to Switch to?

open access: yesJournal of Cognition, 2021
Recent research has shown that humans are able to implicitly adapt to time-transition contingencies in a task-switching paradigm, indicated by better performance in trials where the task transition (switch vs.
Stefanie Aufschnaiter   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy