Results 81 to 90 of about 96,590 (303)

Comparison of the effect of rest interval between sets and set – repetition configuration during bouts of eccentric exercise on muscle damage and inflammatory markers

, 2018
Background and Objective: Various studies have demonstrated that different rest Intervals has a significant effect on hormonal, metabolic and cardiovascular responses. This factors can lead to different muscle damage responses.
Mohammad Esmaiel Afzalpour, Hossein Mohammadi, Seyed Hossein Abtahi Ivary   +2 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Calculation of seismic regime parameters on the basis of a probabilistic model of Kamchatka earthquake catalogue

E3S Web of Conferences, 2016
In the present paper on the basis of a probabilistic interpretation of the earthquake repetition law, simple formulas were obtained which allow us from the known number of earthquake events in a representative interval of energy class (magnitude) to ...
Bogdanov Vadim, Pavlov Aleksey
doaj   +1 more source

Solid-state YVO4/Nd:YVO4/KTP green laser system for the generation of subnanosecond pulses with adjustable kilohertz repetition rate

, 2013
A solid-state green laser generating subnanosecond pulses with adjustable kilohertz repetition rate is presented. This pulse laser system is composed of a Q-switched and mode-locked YVO4/Nd:YVO4/KTP laser simultaneously modulated by an electro-optic ...
Li, Dechun, Wang, Yonggang, Yang, Kejian, Zhang, Haijuan, Li, Guiqiu, Zhao, Shengzhi, Zhao, Jia   +6 more
core   +1 more source

Reducing bias in auditory duration reproduction by integrating the reproduced signal [PDF]

, 2013
Duration estimation is known to be far from veridical and to differ for sensory estimates and motor reproduction. To investigate how these differential estimates are integrated for estimating or reproducing a duration and to examine sensorimotor biases ...
Müller Hermann J., Hermann J. Müller, Shi, K., Hermann J Müller, Ganzenmüller Stephanie, Shi, Zhuanghua, Ganzenmüller, S., Stephanie Ganzenmüller, Shi Zhuanghua, Ganzenmüller, Stephanie, Müller, Hermann J., Zhuanghua Shi   +11 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Rigorous Benchmarking in Reasonable Time [PDF]

, 2013
Experimental evaluation is key to systems research. Because modern systems are complex and non-deterministic, good experimental methodology demands that researchers account for uncertainty.
Tomas Kalibera, Jones, Richard E., Kalibera, Tomas, Richard Jones   +3 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Interaction of repetition and retention interval influences the transfer effect after answer feedback for episodic memory

Frontiers in Psychology
IntroductionRetrieval practice with answer feedback is an efficient way to enhance episodic memory, but previous studies fail to find a robust transfer of learning for non-trained information.
Lingwei Wang, Jiongjiong Yang
doaj   +1 more source