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Background Bone metastases can compromise the integrity of the spinal canal and cause epidural spinal cord compression (ESCC). The Spinal Instability Neoplastic Score (SINS) was developed in order to evaluate spinal instability due to a neoplastic ...
Lukas Bobinski+4 more
doaj +1 more source
Distributional Invariances and Interventional Markov Equivalence for Mixed Graph Models [PDF]
The invariance properties of interventional distributions relative to the observational distribution, and how these properties allow us to refine Markov equivalence classes (MECs) of DAGs, is central to causal DAG discovery algorithms that use both interventional and observational data.
arxiv
Fitness professionals’ pedagogical intervention [PDF]
It is recognised the importance of fitness professionals’ intervention for fitness centres’ quality and participants’ satisfaction and retention. The objective of this article is to present several studies that show some particular aspects of pedagogical
Franco, Susana, Simões, Vera
core
Knowing differently in systemic intervention [PDF]
© 2015 John Wiley & Sons, Ltd. This paper makes the case for extended ways of knowing in systemic intervention. It argues that the deployment of formal (even reflective) thinking and dialogue methods are inadequate, on their own, to the critical tasks ...
Midgley, Gerald, Rajagopalan, Raghav
core +1 more source
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke+2 more
wiley +1 more source
Effect of educational intervention on perceived susceptibility self-efficacy and DMFT of pregnant women [PDF]
Background: The World Health Organization identifies oral health as a necessity for public health through the entirety of life. This issue has been considerably addressed due to susceptibility to tooth decay during pregnancy and maternal and fetal health.
Charkazi, A.+5 more
core +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
In this study, we sought to investigate the mechanisms of action of miR-195-5p in the osteogenic differentiation of vascular smooth muscle cells (VSMCs), and thereby provide novel insights and a reference for the targeted therapy of arterial media ...
Wei Lin+4 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Blood–brain barrier (BBB) disruption may contribute to cognitive decline, but questions remain whether this association is more pronounced for certain brain regions, such as the hippocampus, or represents a whole-brain mechanism.
Tomas Vikner+6 more
doaj +1 more source