Results 151 to 160 of about 6,946,462 (313)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A Customised, Intensive Parent-Child Interaction Therapy for Children With Down Syndrome: Findings From a Real-World Pilot Effectiveness Study. [PDF]

Int J Lang Commun Disord
O'Toole C, Moloney H, McCarthy C, Vousden S, O'Sullivan A, Flynn D, Stokes S, Quinn ED, Frizelle P.   +8 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Short Report: Intervention of Reading and Spelling Problems in Children With Co-Occurring Attention-Deficit Hyperactivity Disorder and Dyslexia. [PDF]

Dyslexia
Verwimp CT, Meiboom N, Tijms J.
europepmc   +1 more source

Intervention toolkit [PDF]

, 2003

core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Participation in a 20-Year Randomized Dietary Trial and University Enrollment. [PDF]

Health Sci Rep
Viinikainen J, Heineck G, Böckerman P, Pahkala K, Jula A, Kari JT, Lagström H, Niinikoski H, Pehkonen J, Rovio SP, Rönnemaa T, Salo P, Viikari J, Raitakari O.   +13 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

204:oral COVID-19 vaccine procurement strategy in Thailand: political economy perspective

BMJ Global Health, 2022
Yot Teerawattananon, Saudamini Dabak, Praewa Kulatnam, Nuttakarn Budtarad   +3 more
doaj   +1 more source

'Better Conversations With Developmental Language Disorder': Designing a Novel Intervention for School-Aged Children and Their Main Carers. [PDF]

Int J Lang Commun Disord
Hughes L, Croot L, Newton C, Best W.
europepmc   +1 more source