Results 91 to 100 of about 511,950 (315)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Effectiveness of Counseling Through Vasectomy Module in North Kolaka, Indonesia [PDF]

, 2017
The main problem faced nowadays is the low participation of men in terms of implementation of the Family Planning Program. The figures for family planning in Indonesia only demonstrate a high rate on contraception use in women not in men. The Strategy to
Askrening, A. (Askrening), Yulita, H. (Hendra)   +1 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Impact of an educational intervention regarding tobacco counseling on dentists and dental students [PDF]

Brazilian Oral Research
: The present study aimed to assess the knowledge, attitudes, and perceptions of dental professionals and students regarding tobacco cessation counseling (TCC) after their participation in a continuing education activity (CEA) entitled "Smoking cessation:
Tiago Luís Herpich, Eduarda Martins Mendes, Michelle Roxo-Gonçalves, Natan Katz, Janete Dias Almeida, Manoela Domingues Martins, Juliana Romanini, Vinicius Coelho Carrard   +7 more
doaj   +1 more source

COUNSELING FOR PRE MARITAL SEX BEHAVIOUR IN ADOLESCENT [PDF]

, 2009
In this 20th century, technology development becomes very fast, includes internet. This condition gave easiest and fastest way to access any kind of information, including pornography.
Rahaju, Soerjantini
core  

Efficacy of HIV/STI behavioral interventions for heterosexual African American men in the United States: a meta-analysis [PDF]

, 2012
This meta-analysis estimates the overall efficacy of HIV prevention interventions to reduce HIV sexual risk behaviors and sexually transmitted infections (STIs) among heterosexual African American men.
Aupont, Latrina W., Charania, Mahnaz R., Crepaz, Nicole, Henny, Kirk D., Jacobs, Elizabeth D., Kay, Linda S., Liau, Adrian, Lyles, Cynthia M., Marshall, Khiya J., Rama, Sima, Willis, Leigh A.   +10 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Enhancing Accessibility, Engagement, and Motivation in Counseling Services for Secondary Schools through Gamified Blended Mobile and Virtual Reality Therapy

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi
Background: Secondary school counseling services often face challenges such as limited counselor availability and low student participation. Traditional counseling methods frequently fail to engage students, thus reducing both accessibility and impact ...
Putri Taqwa Prasetyaningrum, Norshahila Ibrahim, Eka Aryani, Rully Ningsih, Ibnu Rivansyah Subagyo   +4 more
doaj   +1 more source

Smoking Cessation Interventions After Lung Cancer Screening Guideline Change [PDF]

, 2020
Introduction: Recent guideline changes for lung cancer screening with low-dose computed tomography recommend smoking cessation interventions be done in parallel with screening. The purpose of this study is to determine the post-guideline rates of smoking
Chung, Sukyung, Li, Jiang, Luft, Harold S, Martinez, Meghan   +3 more
core   +1 more source