Results 81 to 90 of about 2,363,999 (303)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021 Background & Aim: Infertility is defined as inability to become pregnant with regular sexual intercourse for more than one year without using preventive methods. Infertility has negative effects on the quality of life of infertile couples.
Tayebeh Mokhtari Sorkhani +4 more
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
An assessment of counseling needs of international students at the University of Wisconsin-Stout Spring 2003 [PDF]
, 2003 Plan BThe literature, Pedersen (1996) and Tucker (1991), discusses some issues related to counseling needs of international students in the United States, but there is little empirical data related to international students’ counseling needs, or ...
Hsu, Pu-Yun
core
Tailored System to Deliver Behavioral Intervention and Manage Data in Randomized Trials
Journal of Medical Internet Research, 2013 BackgroundThe integrity of behavioral intervention trials depends on consistent intervention delivery, and uniform, comprehensive process data collection.
Zheng, Hua +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Whither consumer credit counseling? [PDF]
Bob Hunt outlines the history of credit counseling in the U.S. He also observes that, despite its long track record, the credit counseling industry is not without controversy.
Robert M. Hunt
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
“Action Counseling” Intervention for Families in Bosnia-Herzegovina
Procedia - Social and Behavioral Sciences, 2015 AbstractThe Bosnian War was one of the most destructive wars to civilian populations in the history of humanity. Bosnia-Herzegovina has been referred to as a “spectre of a lost future” (Kurtovic, 2014). Associazione Fabio Vita nel Mondo ONLUS (AFVM) is an Italian organization that has been carrying out humanitarian operations since 2003. It is fighting
openaire +1 more source