Results 61 to 70 of about 4,008,724 (388)

Reality Versus Grant Application Research “Plans” [PDF]

, 2018
This article describes the implementation of the American Indian mHealth Smoking Dependence Study focusing on the differences between what was written in the grant application compared to what happened in reality.
Addo, Ivor D., Ahamed, Sheikh Iqbal, Ahsan, Golam Mushih Tanimul, Bordeaux, Simone, Burhansstipanov, Linda, Cina, Krisin, Crawford, Kimberly, Dignan, Mark, Kanekar, Shalini, Krebs, Linda U., Petereit, Daniel, Sargent, Michele, Thibeault, Doris, Williams, Drew   +13 more
core   +1 more source

Study protocol: The Adherence and Intensification of Medications (AIM) study - a cluster randomized controlled effectiveness study [PDF]

, 2010
Background Many patients with diabetes have poor blood pressure (BP) control. Pharmacological therapy is the cornerstone of effective BP treatment, yet there are high rates both of poor medication adherence and failure to intensify medications ...
Bosworth, Hayden B, Heisler, Michele M., Hofer, Timothy P., Hogan, Mary M., Kerr, Eve A., Klamerus, Mandi L., Schmittdiel, Julie, Selby, Joe V., Tremblay, Adam   +8 more
core   +5 more sources

Pre-counseling Education for Low Literacy Women at Risk of Hereditary Breast and Ovarian Cancer (HBOC): Patient Experiences Using the Cancer Risk Education Intervention Tool (CREdIT)

Journal of Genetic Counseling, 2010
The Cancer Risk Education Intervention Tool (CREdIT) is a computer-based (non-interactive) slide presentation designed to educate low-literacy, and ethnically and racially diverse public hospital patients at risk of Hereditary Breast and Ovarian Cancer ...
Galen Joseph, M. Beattie, Robin Lee, D. Braithwaite, C. Wilcox, M. Metrikin, Kate Lamvik, J. Luce   +7 more
semanticscholar   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

A systematic review of interventions in primary care to improve health literacy for chronic disease behavioral risk factors [PDF]

, 2012
Background: To evaluate the effectiveness of interventions used in primary care to improve health literacy for change in smoking, nutrition, alcohol, physical activity and weight (SNAPW).
Dennis, S, Denny-Wilson, E, Harris, M, Newall, A, Shortus, T, Taggart, J, Williams, A, Zwar, N   +7 more
core   +4 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Beyond intention-to-treat: The effect of brief counseling for tobacco cessation in secondary analyses of a cluster randomized controlled trial in Swedish dental clinics

Contemporary Clinical Trials Communications, 2017
In experimental studies the assigned intervention measures the received intervention if full protocol adherence is achieved, but this is rarely the case in public health.
Sinziana I. Oncioiu, Livia Franchetti-Pardo, Suvi E. Virtanen, Fabrizio Faggiano, Maria R. Galanti   +4 more
doaj   +1 more source