Results 251 to 260 of about 1,819,629 (315)

Model-informed precision dosing of vancomycin in clinical practice: an intervention development study. [PDF]

Int J Clin Pharm
Swartling M, Hamberg AK, Furebring M, Tängdén T, Nielsen EI.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A clinical nomogram for predicting major adverse cardiovascular and cerebrovascular events in elderly Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention: development and validation in a real-world cohort. [PDF]

J Geriatr Cardiol
Xu JJ, Li QX, Yuan DS, Wang PZ, Hao YC, Zhu P, Song Y, Yao Y, Jiang L, Wang JY, Zhao XY, Song L, Yuan JQ, Zhang Y.   +13 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A new role profile for nurses with expanded competencies promoting person-centered care in long-term care: a mixed-methods intervention development study. [PDF]

BMC Geriatr
Silies K, Huckle T, Pohontsch N, Jarchow AM, Schütz K, Müller M, Lühmann D, Balzer K.   +7 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Extra-uterine placental transfusion and intact-cord stabilisation of infants in caesarean sections: an intervention development and pilot-study (INTACT-1). [PDF]

BMC Pregnancy Childbirth
Saether E, Andersson O, Bjellmo S, Bernitz S, Reinhart-Van Gülpen F, Myklebust TÅ, Stridsklev S, Eriksen BH.   +7 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Trial Enrollment Diversity Dashboard for Acute Leukemia Clinical Research: Intervention Development and Cohort Analysis. [PDF]

JCO Oncol Pract
Hantel A, Walsh TP, Li KY, Awan S, Littlejohn E, Lathan CS, Abel GA.   +6 more
europepmc   +1 more source

Exploring Stress and Stress-Reduction With Caregivers and Clinicians in the Neonatal Intensive Care Unit to Inform Intervention Development: Qualitative Interview Study. [PDF]

JMIR Pediatr Parent
Ginsberg KH, Alsweiler J, Rogers J, Ross P, Serlachius A.   +4 more
europepmc   +1 more source