Results 91 to 100 of about 626,120 (309)

Observational-Interventional Priors for Dose-Response Learning [PDF]

, 2016
Controlled interventions provide the most direct source of information for learning causal effects. In particular, a dose-response curve can be learned by varying the treatment level and observing the corresponding outcomes. However, interventions can be
Silva, Ricardo
core   +1 more source

Graphical models for mediation analysis

, 2018
Mediation analysis seeks to infer how much of the effect of an exposure on an outcome can be attributed to specific pathways via intermediate variables or mediators. This requires identification of so-called path-specific effects.
Steen, Johan, Vansteelandt, Stijn
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Interventional Combined Microwave Ablation for Primary Neuroendocrine Carcinoma of the Liver Failing Systemic Chemotherapy: A Case Report

Journal of Hepatocellular Carcinoma
Yang Fang, Xiuying Jin, Huiying Cui, Zhezhu Han, Qiang Xu, Songnan Zhang Department of Oncology, Yanbian University Hospital, Yanji, People’s Republic of ChinaCorrespondence: Songnan Zhang, Email zhangsn21@163.comBackground: Primary hepatic ...
Fang Y, Jin X, Cui H, Han Z, Xu Q, Zhang S   +5 more
doaj  

How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia is an age‐related muscle disease often accompanied by comorbidities, mobility issues and cognitive decline, which can limit treatment adherence in older adults.
Sophie Van Heden, Zoubayda Baoubbou, Dolores Sanchez‐Rodriguez, Yoke Mun Chan, Charlotte Beaudart   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Interventional sialendoscopy [PDF]

The Laryngoscope, 2000
Marchal, Francis, Becker, Minerva, Dulguerov, Pavel, Lehmann, Willy   +3 more
openaire   +5 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Ultrasound-guided semispinalis obliquus plane block for posterior upper cervical spine surgery: Technical description and case series

Indian Journal of Anaesthesia
Posterior upper cervical spine surgeries are associated with significant postoperative pain due to extensive soft tissue and muscular dissection, leading to increased nociception transmitted via multi-segmental dorsal rami innervation.
Tuhin Mistry, Kartik Sonawane, Natarajan Vivekanandan, BalavenkataSubramanian Jagannathan   +3 more
doaj   +1 more source