Results 171 to 180 of about 10,035,950 (291)

Letter to the Editor: Multimodal interventions for pain management

Australian Prescriber, 2022
Sarah Abrahamson, Gloria Wong
openaire   +2 more sources

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Interventional pain management focused on zygapophysial joint pain: current landscape and future perspectives. [PDF]

Pain Manag
Hambraeus J.
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Correction to: Delphi-Based Expert Consensus Statements for the Management of Percutaneous Radiofrequency Neurotomy in the Treatment of Lumbar Facet Joint Syndrome

Pain and Therapy, 2023
Felice Occhigrossi, Roberta Carpenedo, Matteo Luigi Giuseppe Leoni, Giustino Varrassi, Elisabetta Chinè, Marco Cascella, Compain Research Group   +6 more
doaj   +1 more source

Interventional pain management in dogs with lumbosacral stenosis: preliminary long-term clinical outcomes of combined foraminal and epidural injections with or without pulsed radiofrequency. [PDF]

Front Vet Sci
Medina-Serra R, Laredo FG, de Strobel F, Sanchis-Mora S, Belda E.   +4 more
europepmc   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

The Optimal Patient Profile and Appropriate Role of Spinal Cord Stimulation (SCS) for Patients with Persistent Spinal Pain Syndrome-Type 1 (PSPS-T1) Not Suitable for Spine Surgery: A European Modified Delphi Consensus

Journal of Pain Research
Tobias L Schulte,1 María Reyes Fernández-Marín,2 Roberto Gazzeri,3 Oliver Hamel,4 Jan Willem Kallewaard,5,6 Kavita Poply,7,8 Iris Smet,9 Jan Vesper,10 Erik Van de Kelft11,12 1Department of Orthopedics and Trauma Surgery, Katholisches Klinikum Bochum - St.
Schulte TL, Fernández-Marín MR, Gazzeri R, Hamel O, Kallewaard JW, Poply K, Smet I, Vesper J, Van de Kelft E   +8 more
doaj  

Interventional pain management of CRPS in the pediatric population: A literature review. [PDF]

Interv Pain Med
Mosquera-Moscoso J, Eldrige J, Encalada S, Mendonca LFP, Hallo-Carrasco A, Shan A, Rabatin A, Mina M, Prokop L, Hunt C.   +9 more
europepmc   +1 more source