Results 261 to 270 of about 3,907,428 (327)

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Direct-view endoscopic ultrasound-guided fibrotic hepaticojejunostomy stricture managed with a modified stent tube. [PDF]

Endoscopy
Soga K, Yamaguchi M, Kuwada M, Shirahashi R, Kobori I, Tamano M.   +5 more
europepmc   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Evaluation of difficult laryngoscopy with ultrasonography in pediatric patients: Prospective study. [PDF]

Medicine (Baltimore)
Kaya O, Şanal S, Onay M.
europepmc   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source

Endoscopic ultrasound-guided gallbladder drainage and electrohydraulic lithotripsy for the treatment of gallbladder neck stones. [PDF]

Endoscopy
Wang Y, Dong Q, Li L, Liu X, Li W, Li Q.
europepmc   +1 more source

Ruptured Baker's Cyst Demystified: Current Evidence, Diagnostic Strategies, and Treatment Options for an Under-Recognized Condition. [PDF]

Cureus
Zmerly H, Di Lorenzo L, Mahfouz V, Sciarretta FV, Pegreffi F.   +4 more
europepmc   +1 more source

Radiologic imaging and its current importance in breast cancer management. [PDF]

Front Radiol
Dagar N, Sarin M, Yadav P, Thidwar R.
europepmc   +1 more source

Differential Diagnosis of Posterior Buttock Pain: A Conceptual Review Based on Topographic Localization of Pain, Is It Really the Sacroiliac Joint? [PDF]

Int J Spine Surg
Reckling WC, Polly DW.
europepmc   +1 more source

Testicular Compartment Syndrome Post Bilateral Microdissection Testicular Sperm Extraction: A Case Report and Review of the Current Literature. [PDF]

Case Rep Urol
Larard C, McComb K, Donkov I, Coscione A, Nikolinakos P, Pang KH.   +5 more
europepmc   +1 more source