Results 81 to 90 of about 43,436 (258)

Machine learning and single-cell analysis identify the mitophagy-associated gene TOMM22 as a potential diagnostic biomarker for intervertebral disc degeneration

Heliyon
Background: Mitophagy selectively eliminates potentially cytotoxic and damaged mitochondria and effectively prevents excessive cytotoxicity from damaged mitochondria, thereby attenuating inflammatory and oxidative responses.
Yinghao Wu, Shengting Wu, Zhiheng Chen, Erzhu Yang, Haiyue Yu, Guowang Zhang, XiaoFeng Lian, JianGuang Xu   +7 more
doaj   +1 more source

Treatment of discospondylitis in dogs: A systematic review

Veterinary Record, EarlyView.
Abstract Background Both medical and surgical techniques have been reported to manage canine discospondylitis, although data on clinical effectiveness and long‐term prognosis remain limited. Methods A systematic review of studies on treatment approaches, follow‐up data and investigation methods was conducted.
Vasileios Ioannis Vallios, Evdokia Sourla, Daniel Low, Holger A. Volk, Marios Charalambous   +4 more
wiley   +1 more source

Clinical reasoning in feline non‐ambulatory tetraparesis or tetraplegia: Which combination of clinical information is useful?

Veterinary Record, EarlyView.
Abstract Background Non‐ambulatory tetraparesis or tetraplegia in cats may constitute a diagnostic challenge for general practitioners. Therefore, this study aimed to evaluate if clinical variables from signalment, history, clinical examination and basic ancillary tests are associated with underlying diagnoses in cats with non‐ambulatory tetraparesis ...
Guido Bertoldi, Steven De Decker
wiley   +1 more source

Evaluation of Intervertebral Disc Space Width Between 10th and 11th Thoracic Vertebrae in Cats Using Radiography and Magnetic Resonance Imaging

Veterinary Medicine and Science
Background It is well known that the T10–T11 intervertebral disc space is usually narrower than the adjacent intervertebral disc spaces in most dogs.
Jiwon Kim, Danbee Kwon, Bumseok Kim, Kichang Lee, Hakyoung Yoon   +4 more
doaj   +1 more source

The causality between smoking and intervertebral disc degeneration mediated by IL-1β secreted by macrophage: A Mendelian randomization study

Heliyon
There is still a lack of high-level evidence regarding the causal relationship between smoking and intervertebral disc degenerative diseases. This study utilized data from genome wide analysis studies and conducted two-sample Mendelian randomization ...
Zhaopu Han, Yicheng Chen, Xiaojian Ye
doaj   +1 more source

Inter‐rater agreement of the canine modified Ashworth scale for assessment of limb tone in dogs presenting with acute myelopathic signs

Veterinary Record, EarlyView.
Abstract Background This study aimed to assess the inter‐rater reliability of a canine adaptation of the modified Ashworth scale (CaMAS) for the assessment of muscle tone in dogs. Methods Dogs presented to the neurology service of a single referral centre between November 2023 and October 2024 underwent a muscle tone evaluation by two independent ...
Albert Aguilera‐Padros, Joao M. De Frias, Megan Madden, Ana Oliveira, Callum Atkins, Ivona Orgonikova, Aran Nagendran   +6 more
wiley   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Osteological, Biological, and Genetic Consequences of Colonization of Fresh Waters by Marine Cottoid Fishes (Cottidae)

Integrative Zoology, EarlyView.
Lacustrine forms of Triglopsis from North American and European lakes are at different stages of evolution, making them a suitable model for testing hypotheses about evolutionary patterns and rates. An integrative analysis of morphological, genetic, and biological adaptations occurring in lacustrine forms of the genus Triglopsis was carried out.
Valentina G. Sideleva, Zakhar V. Zhidkov, Nataliia V. Annenkova, Alexander G. Ryumin, Danila A. Melentev   +4 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source