Advanced Science, EarlyView.A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu +10 more
wiley +1 more source
The effects of physiological biomechanical loading on intradiscal pressure and annulus Stress in lumbar spine: a finite element analysis [PDF]
, 2017 The present study was conducted to examine the effects of body weight on intradiscal pressure (IDP) and annulus stress of intervertebral discs at lumbar spine.
Kadir, M. R. A. +4 more
core +2 more sources
Advanced Science, EarlyView.Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin +5 more
wiley +1 more source
Relation between grades of intervertebral disc degeneration and occupational activities of patients with lumbar disc herniation [PDF]
Vojnosanitetski Pregled, 2017 Background/Aim. Intervertebral disc degeneration (IDD) occurs as consequence of combined effects of genetic, agerelated, environmental and occupational factors. Lumbar disc herniation (LDH) develops mostly due to IDD.
Papić Monika +5 more
doaj +1 more source
An overview of the postcranial osteology of caecilians (Gymnophiona, Lissamphibia)
The Anatomical Record, EarlyView.Abstract Caecilians comprise a relatively small (~220 species) group (Gymnophiona) of snake‐like or worm‐like, mostly tropical amphibians. Most adult caecilians are fossorial, although some species may live in aquatic or semi‐aquatic environments, either as larvae or adults.
Rodolfo Otávio Santos +2 more
wiley +1 more source
Aberrant intervertebral motion in patients with treatment‑resistant nonspecific low back pain: a retrospective cohort study and control comparison [PDF]
, 2018 Purpose Intervertebral kinematic assessments have been used to investigate mechanical causes when back pain is resistant to treatment, and recent studies have identified intervertebral motion markers that discriminate patients from controls.
Breen, Alan C. +2 more
core +1 more source
The Anatomical Record, EarlyView.Abstract The upper carbonate concretion levels of the Romualdo Formation (Aptian, Brazil) have yielded several theropod dinosaur remains, including spinosaurids and the coelurosaurs Santanaraptor placidus and Mirischia asymmetrica, the phylogenetic affinities of which are controversial.
Rafael Delcourt +4 more
wiley +1 more source
Morphological variation in atlas and axis of Neotropical spiny rats (Rodentia, Echimyidae)
The Anatomical Record, EarlyView.Abstract The unique morphologies of the first two cervical vertebrae, the atlas and axis, represent a significant innovation in mammalian evolution. These structures support the weight of the head and enable intricate movements of the head and neck.
Thomas Furtado da Silva Netto +3 more
wiley +1 more source
Failure mechanical properties of lumbar intervertebral disc under high loading rate
Journal of Orthopaedic Surgery and ResearchBackground Lumbar disc herniation (LDH) is the main clinical cause of low back pain. The pathogenesis of lumbar disc herniation is still uncertain, while it is often accompanied by disc rupture.
Qing Liu +6 more
doaj +1 more source
The conservative treatment of cervical hernia in dogs: the importance of respecting procedures – A case study [PDF]
Medicamentul Veterinar, 2019 The intervertebral disk herniation is an abnormal disposal of the nucleus pulposus and/or annulus fibrosus. The displacement can be found in the vertebral canal and/or intervertebral foramen.
Anca Bulai +2 more
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