Results 101 to 110 of about 8,848 (204)
JOR SPINE, Volume 9, Issue 3, September 2026.We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang +8 more
wiley +1 more source
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, Volume 13, Issue 43, 3 August 2026.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source
SARS‐CoV‐2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways
European Journal of Pain, Volume 30, Issue 7, August 2026.ABSTRACT Background Pain is a common neurological manifestation of COVID‐19, yet the mechanisms by which SARS‐CoV‐2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike‐derived peptides directly activate spinal neuroimmune pathways involved in pain signalling.
Bruno Eduardo Silva +15 more
wiley +1 more source
Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley +1 more source
Small Science, Volume 6, Issue 8, August 2026.A compact laboratory X‐ray system enables directional dark‐field imaging and tomography with sensitivity to scattering along two orthogonal directions. The approach provides volumetric mapping of sub‐resolution microstructure in engineering and biological samples, which reveals structural heterogeneity, fiber organization, and anisotropic scattering ...
Carlos Navarrete‐León +11 more
wiley +1 more source
Medicochirurgical description of patients operated on due to a diagnosis of lumbar disc herniation
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018 Background: disc disease is a world health problem nowadays. The adequate application of the selection criteria for the patients with lumbar disc herniation and the performance of a sophisticated surgical technique are significant for getting good short ...
Lissett Ponce-de-León-Norniella +4 more
doaj
Staging concept for aging management: Definition, mechanism, and coping strategies
VIEW, Volume 7, Issue 4, August 2026.We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
Síndrome de la cauda equina, caso clínico radiológico
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019 El síndrome de la cauda equina es una emergencia quirúrgica de la columna lumbar, que se caracteriza por un conglomerado de síntomas y signos que incluye el dolor lumbar con ciática, trastornos disfuncionales de la micción, la defecación, el ...
Alexander Sosa-Frias +2 more
doaj
Pharmacological Inhibition of Cav2.2 Channels by Recombinant Phα1β Toxin (CTK01512‐2)
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.The recombinant Phα1β toxin (CTK01512‐2) partially and reversibly inhibits Cav2.2 calcium channels in HEK‐293 cells. CTK01512‐2 displays dose‐dependent inhibition of N‐type calcium currents, with an IC50 of 3.94 nM. In vivo, CTK01512‐2 effectively reduces mechanical allodynia in a neuropathic pain model, confirming its antinociceptive activity ...
Natália Virtude Carobin +5 more
wiley +1 more source
Journal of Anatomy, Volume 249, Issue 2, Page 435-444, August 2026.This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne +7 more
wiley +1 more source