Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema
Allergy, EarlyView.This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery +25 more
wiley +1 more source
The conservative treatment of cervical hernia in dogs: the importance of respecting procedures – A case study [PDF]
Medicamentul Veterinar, 2019 The intervertebral disk herniation is an abnormal disposal of the nucleus pulposus and/or annulus fibrosus. The displacement can be found in the vertebral canal and/or intervertebral foramen.
Anca Bulai +2 more
doaj
Clinical application of ceramics in anterior cervical discectomy and fusion: A review and update [PDF]
, 2017 Study Design: Narrative review. Objectives: Anterior cervical discectomy and fusion (ACDF) is a reliable procedure, commonly used for cervical degenerative disc disease. For interbody fusions, autograft was the gold standard for decades; however, limited
Abedi, Aidin +5 more
core +2 more sources
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Failure mechanical properties of lumbar intervertebral disc under high loading rate
Journal of Orthopaedic Surgery and ResearchBackground Lumbar disc herniation (LDH) is the main clinical cause of low back pain. The pathogenesis of lumbar disc herniation is still uncertain, while it is often accompanied by disc rupture.
Qing Liu +6 more
doaj +1 more source
Rheological and mechanical properties of acellular and cellladen methacrylated gellan gum hydrogels [PDF]
, 2013 Tissue engineered hydrogels hold great potential as nucleus pulposus substitutes (NP), as they promote intervertebral disc (IVD) regeneration and re-establish its original function.
Ambrosio, L. +6 more
core +1 more source
Cell Proliferation, EarlyView.Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang +14 more
wiley +1 more source
Ultrasound imaging of cervical spine motion for extreme acceleration environments [PDF]
, 2011 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2011.Cataloged from PDF version of thesis. Vita.Includes bibliographical references (p.
Buckland, Daniel Miller
core
Biomechanical and in vivo evaluation of experimental closure devices of the annulus fibrosus designed for a goat nucleus replacement model [PDF]
, 2010 Promising strategies are being developed to replace or regenerate the herniated nucleus pulposus. However, clinical efficacy of these methods has still to be addressed, and the lack of appropriate annulus closure techniques is increasingly being ...
Johannes L. Bron +6 more
core +2 more sources
The FEBS Journal, EarlyView.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source