Results 91 to 100 of about 9,151 (264)

Tissue Engineering Strategies For Total Disc Replacement: Structure And Mechanical Function Of The Intervertebral Disc

, 2021
151 pagesDegenerative disc disease (DDD) is implicated as one of the primary causes of lower back pain (LBP), the leading cause of disability worldwide.
Lintz, Marianne
core   +1 more source

Fiber Bragg Grating Force Sensors for Minimally Invasive Surgery: State of the Art, Challenges, and Opportunities

SmartBot, EarlyView.
This article reviews the application of fiber Bragg grating (FBG) technology for precise force sensing in minimally invasive surgery. It outlines the fundamental working principles and algorithms used to interpret sensor data. The text surveys clinical applications across various medical fields, such as ophthalmology and vascular intervention (Table of
Shiyuan Dong, Tianqi Huang, Lingyu Chen, Shucong Yin, Qing Chang, Dingpei Han, Yangxi Li, Boyu Zhang, Hongen Liao, Fang Chen   +9 more
wiley   +1 more source

Pathophysiologic aspects of resorption of intervertebral disk hernia

, 2019
Spinal disc herniation is a pathological anatomical disorder that is associated with localized disk displacement beyond the intervertebral space. Although in most cases surgical intervention is not necessary for recovery, it still has an important role ...
Elena S. Akarachkova, Artem V. Iliushin, Anton V. Epifanov, Alexsander M. Tkachev, Daniil S. Archakov, Alina V. Smirnova   +5 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Failure mechanical properties of lumbar intervertebral disc under high loading rate

Journal of Orthopaedic Surgery and Research
Background Lumbar disc herniation (LDH) is the main clinical cause of low back pain. The pathogenesis of lumbar disc herniation is still uncertain, while it is often accompanied by disc rupture.
Qing Liu, Xiao-Feng Liang, Ai-Guo Wang, Ying Liu, Tong-Ju Jia, Kun Li, Chun-Qiu Zhang   +6 more
doaj   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

REHABILITATION AFTER LUMBAR INTERVERTEBRAL DISC PROTRUSION SURGERY

, 2021
Cilj: Cilj ovog rada je pretragom medicinskih baza podataka napraviti narativni pregled literature o trenutno dostupnim rehabilitacijskim postupcima nakon operacije protruzije lumbalnog intervertebralnog diska i na temelju dobivenih rezultata opisati ...
Rozić, Vinka
core  

In vivo intervertebral disc deformation: intratissue strain patterns within adjacent discs during flexion–extension

, 2021
The biomechanical function of the intervertebral disc (IVD) is a critical indicator of tissue health and pathology. The mechanical responses (displacements, strain) of the IVD to physiologic movement can be spatially complex and depend on tissue ...
Nauman, Eric A, Schneider, Stephanie Ellyse, Robert L. Wilson, Cai, Luyao, Leah Bowen, Kim, Woong, Neu, Corey P, Corey P. Neu, Wilson, Robert L, Eric A. Nauman, Woong Kim, Luyao Cai, Stephanie Ellyse Schneider, Bowen, Leah   +13 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source