Results 131 to 140 of about 13,470 (264)

Advancing Intervertebral Disc Biology via Omics: Implications for Nucleus Pulposus Progenitor Cell‐Based Regeneration

JOR SPINE, Volume 8, Issue 4, December 2025.
Intervertebral disc degeneration (IDD) is a multifactorial condition underpinned by complex molecular mechanisms. This review highlights advances in RNA sequencing and multi‐omics approaches that have elucidated gene regulatory networks, cellular heterogeneity, and progenitor cell dynamics in the nucleus pulposus.
Anja Stirnimann, Leon Schlagenhof, Benjamin Gantenbein, Fabian Ille   +3 more
wiley   +1 more source

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

Radiomics based on MRI to predict recurrent L4-5 disc herniation after percutaneous endoscopic lumbar discectomy

BMC Medical Imaging
Background In recent years, radiomics has been shown to be an effective tool for the diagnosis and prediction of diseases. Existing evidence suggests that imaging features play a key role in predicting the recurrence of lumbar disk herniation (rLDH ...
Antao Lin, Hao Zhang, Yan Wang, Qian Cui, Kai Zhu, Dan Zhou, Shuo Han, Shengwei Meng, Jialuo Han, Lei Li, Chuanli Zhou, Xuexiao Ma   +11 more
doaj   +1 more source

Spinal ataxia and computed tomography findings in a Poitou donkey affected with congenital occipitoatlantoaxial malformation

Equine Veterinary Education, Volume 37, Issue 11, Page e261-e265, November 2025.
Summary A 3‐year‐old Poitou donkey was referred for a computed tomography (CT) examination of the cervical spine due to acute deterioration of spinal ataxia. Neurological assessment revealed restricted neck mobility, hypermetria and circumduction of all limbs, indicating a grade 2 out of 5 ataxia.
M. Mikic, F. Frers, L. Wittenberg‐Voges, M. Hellige   +3 more
wiley   +1 more source

Corticosteroid Administration to Prevent Complications of Anterior Cervical Spine Fusion: A Systematic Review. [PDF]

, 2018
Study Design: Systematic review. Objectives: Anterior cervical approach is associated with complications such as dysphagia and airway compromise. In this study, we aimed to systematically review the literature on the efficacy and safety of corticosteroid
Abedi, Aidin, Bonaki, Hirbod Nasiri, Jazayeri, Seyed Behnam, Rahimi-Movaghar, Vafa, Vaccaro, Alexander R., Zadegan, Shayan Abdollah   +5 more
core   +1 more source

Phase‐Contrast Magnetic Resonance Imaging Identifies Low Cerebrospinal Fluid Velocity at the Foramen Magnum in Small Breed Dogs With an Enlarged Ventricular System

Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background In small breed dogs, enlarged ventricles of the brain are a common finding on magnetic resonance imaging (MRI). In humans, enlarged lateral ventricles are usually the consequence of mesencephalic aqueduct stenosis. Cerebrospinal fluid (CSF) velocity measurements indicating obstruction are lacking in dogs.
Sarah Hubler, Christina Precht, Gertraud Schüpbach‐Regula, Veronika M. Stein, Daniela Schweizer   +4 more
wiley   +1 more source

Additional file 1: of A survey among Korea Medicine doctors (KMDs) in Korea on patterns of integrative Korean Medicine practice for lumbar intervertebral disc displacement: Preliminary research for clinical practice guidelines

, 2015
Clinical practice of Korean medicine for lumbar intervertebral disc displacement: A survey. The final questionnaire used for collection of data. (DOCX 87Â kb)
Ye-Sle Shin, Joon-Shik Shin, Jinho Lee, Lee, Yoon, Me-Riong Kim, Ahn, Yong-Jun, Park, Ki, Byung-Cheul Shin, Lee, Myeong, Kim, Joo-Hee, Jae-Heung Cho, In-Hyuk Ha   +11 more
openaire   +1 more source

Mapping Human Proprioceptive Projections of Upper Limb Muscles Through Spinal Cord fMRI

Human Brain Mapping, Volume 46, Issue 15, October 15, 2025.
This study uses spinal fMRI combined with muscle vibration to map cervical proprioceptive circuits. It reveals distinct muscle‐specific activation patterns reflecting myotome organization. A deep‐learning model improves precision by accounting for individual anatomical variability, offering a novel approach to understanding the proximo‐distal ...
Raphaëlle Schlienger, Caroline Landelle, Sergio Daniel Hernandez‐Charpak, Daniela Maria Pinzon‐Corredor, Jeanne Caron‐Guyon, Julien Sein, Bruno Nazarian, Jocelyne Bloch, Olivier Felician, Jean‐Luc Anton, Grégoire Courtine, Anne Kavounoudias   +11 more
wiley   +1 more source

Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D‐Printed Titanium Truss

Advanced Healthcare Materials, Volume 14, Issue 27, October 20, 2025.
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo   +9 more
wiley   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source