Results 141 to 150 of about 9,151 (264)

In vivo lumbar spine biomechanics : vertebral kinematics, intervertebral disc deformation, and disc loads

, 2012
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.Cataloged from PDF version of thesis.Includes bibliographical references.Knowledge of lumbar spine biomechanics in living human subjects is fundamental for ...
Wang, Shaobai
core  

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Platelet‐Rich Fibrin Induces New Bone Formation to Promote Extreme Lateral Interbody Fusion of Spine in Rabbits

JOR SPINE, Volume 9, Issue 2, June 2026.
Preparation process of PRF and its promotion of intervertebral fusion. The rabbit lateral fusion model proves that PRF can promote the intervertebral fusion rate of allograft bone. In vitro experiments can be observed that PRF promotes the osteogenic expression of BMSCS.
Weijian Wang, Jiaqi Li, Han Wu, Sidong Yang, Shaorong Li, Wei Zhang   +5 more
wiley   +1 more source

Tratamiento quirúrgico de la hernia discal lumbosacra en el hospital "Ernesto Guevara de la Serna"

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2015
Fundamento: la hernia discal lumbosacra tiene una alta prevalencia en el mundo y en Cuba. El resultado del tratamiento quirúrgico tiene gran impacto individual, familiar, laboral, social y económico.Objetivo: describir los resultados del tratamiento ...
Henry López Jimenez
doaj  

Uncertainty Quantification of Central Canal Stenosis Deep Learning Classifier From Lumbar Sagittal T2‐Weighted MRI

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Accurate assessment of the severity of central canal stenosis (CCS) on lumbar spine MRI is critical for clinical decision‐making. We evaluated deep learning models for automated CCS grading on sagittal T2‐weighted MRI, focusing on uncertainty quantification to improve clinical reliability.
Adriana Brenzikofer, Maria Monzon, Fabio Galbusera, Zina‐Mary Manjaly, Andrea Cina, Catherine R. Jutzeler   +5 more
wiley   +1 more source

Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Chronic low back pain is a leading cause of global disability, with discogenic low back pain (DLBP), mechanically stimulated pain arising from the intervertebral disc, representing an important but often under‐recognized subtype. DLBP arises from chronic structural and metabolic changes within the intervertebral disc, leading to ...
William Roger Peters, Ashish D. Diwan, Mario Giuseppe Zotti   +2 more
wiley   +1 more source

Radiculopatía lumbosacra por hernia discal. Caracterización clínica electrofisiológica. Bayamo 2006-2011

Multimed, 2017
Introducción: las radiculopatías por la compresión de la raíz nerviosa responden a diversas causas que pueden ser hernias discales, espondilosis, tumoraciones, traumatismos.
Betania Aurora Martínez Rodríguez, Yadira Aguilar Jorge, Maythe Peláez Llorente, Kacenys Lao Fernández, Talía Betania Rodríguez Martínez   +4 more
doaj  

Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair

JOR SPINE, Volume 9, Issue 2, June 2026.
Nucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J. O'Brien, Caroline M. Curtin, James E. Dixon, Pieter A. J. Brama, Conor T. Buckley   +7 more
wiley   +1 more source

Pre‐Conditioned Bone Marrow Mesenchymal Stromal Cell‐Derived Secretome Exerts an Anti‐Inflammatory Effect on Degenerative Nucleus Pulposus Cells In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
IL‐1β‐preconditioned BM‐MSC‐derived secretome counteracts inflammation‐driven degeneration in hNPCs. BM‐MSCs were preconditioned with IL‐1β (10 ng/mL) for 24 h, and the resulting secretome (BM‐MSCsec) was collected. Degenerative hNPCs cultured in a 3D alginate bead model were exposed to IL‐1β to reproduce an inflammatory degenerative microenvironment ...
Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Giuseppina Di Giacomo, Claudia Cicione, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro   +7 more
wiley   +1 more source

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity

JOR SPINE, Volume 9, Issue 2, June 2026.
Human intervertebral disc nutrient microenvironment. Changes observed in microenvironmental profile as a result of degeneration outlined on upper vertebral body with ranges of each species as reported in previous studies. Oxygen, glucose, and lactate gradients are profiled across the lower disc in both healthy and degenerated states.
Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley   +6 more
wiley   +1 more source