Results 131 to 140 of about 9,151 (264)
The Journal of Physiology, EarlyView.Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez +7 more
wiley +1 more source
International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 7, July 2026.We present an automated CT‐to‐simulation workflow to estimate structural response and fracture risk in metastasis‐affected vertebrae. Deep learning performs vertebral identification and segmentation, while CPD assigns geometry‐aware boundary conditions.
B. Gandia‐Vañó +4 more
wiley +1 more source
Effect of load frequency on trans-endplate transport of nutrients to the intervertebral disc
, 2015 May 2015School of EngineeringThe model shows that the total nutrient transport to the disc can be augmented by a dynamic load. For healthy and degenerated discs, the maximum total nutrient transport is observed when the loading frequency of the applied ...
Shah, Mitul A.
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Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro
JOR SPINE, Volume 9, Issue 2, June 2026.Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis +4 more
wiley +1 more source
, 2023 Herniated discs in the spine are a significant patient burden, with potential links to lower back and leg discomfort and a considerable impact on daily life.
Kulkarni, Radhika
core
Occupational loading is a significant risk factor for back pain and vertebral joint disease. Although biomechanical principles predict that spinal loading is affected by body proportion, particularly with differences in upper to lower body measurements ...
Pamplin, Gary David
core
A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
JOR SPINE, Volume 9, Issue 2, June 2026.A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
Medicochirurgical description of patients operated on due to a diagnosis of lumbar disc herniation
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018 Background: disc disease is a world health problem nowadays. The adequate application of the selection criteria for the patients with lumbar disc herniation and the performance of a sophisticated surgical technique are significant for getting good short ...
Lissett Ponce-de-León-Norniella +4 more
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JOR SPINE, Volume 9, Issue 2, June 2026.Chronic low back pain in patients without advanced disc degeneration is associated with gut microbiome dysbiosis, marked by reduced microbial diversity and altered bacterial composition. These findings support a gut–disk axis in which impaired gut barrier integrity and systemic inflammation may contribute to disc inflammation, nociceptive fiber ...
Stone Sima +10 more
wiley +1 more source
Síndrome de la cauda equina, caso clínico radiológico
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019 El síndrome de la cauda equina es una emergencia quirúrgica de la columna lumbar, que se caracteriza por un conglomerado de síntomas y signos que incluye el dolor lumbar con ciática, trastornos disfuncionales de la micción, la defecación, el ...
Alexander Sosa-Frias +2 more
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