Results 141 to 150 of about 45,413 (272)

Radiomics based on MRI to predict recurrent L4-5 disc herniation after percutaneous endoscopic lumbar discectomy

BMC Medical Imaging
Background In recent years, radiomics has been shown to be an effective tool for the diagnosis and prediction of diseases. Existing evidence suggests that imaging features play a key role in predicting the recurrence of lumbar disk herniation (rLDH ...
Antao Lin, Hao Zhang, Yan Wang, Qian Cui, Kai Zhu, Dan Zhou, Shuo Han, Shengwei Meng, Jialuo Han, Lei Li, Chuanli Zhou, Xuexiao Ma   +11 more
doaj   +1 more source

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress‐Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy

JOR SPINE, Volume 8, Issue 2, June 2025.
In this study, we utilized LC/MS‐based untargeted metabolomics analysis to examine changes in the metabolite profiles of NP cells under stress conditions. Upon analysis, PE was identified as a differentially abundant metabolite for its decreased content within advanced‐stage NP cells.
Yijun Dong, Chuanfu Li, Shuangshuang Tu, Mingkai Liu, Kai Lv, Liqun Duan, Feng Zhang, Haiping Cai, Xi Chen, Wenzhi Zhang   +9 more
wiley   +1 more source

Multi-vertebral CT-based FE models implementing linear isotropic population-based material properties for the intervertebral discs cannot accurately predict strains [PDF]

arXiv
Vertebral fractures prediction in clinics lacks of accuracy. The most used scores have limitations in distinguishing between subjects at risk or not. Finite element (FE) models generated from computed tomography (CT) of these patients may improve the predictive capability.
arxiv  

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen   +6 more
wiley   +1 more source

Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
This article reviews the role of macrophage polarization in IVDD. It details how macrophage polarization influences various pathomechanisms of disc degeneration, including the inflammatory microenvironment, NPCs senescence, angiogenesis, fibrosis, and neural ingrowth and sensitization.
Kaiyuan Zheng, Siyu Wang, Meng Deng, Yaomin Luo, Wen Li, Lianlin Zeng, Yinxu Wang   +6 more
wiley   +1 more source

A Web-based Survey for Assessment of Korean Medical Treatment Clinical Practice Patterns for Neck Pain and Cervical Intervertebral Disc Displacement※ [PDF]

, 2016
Chang Yong Suh, Yoon Jae Lee, Me-riong Kim, Young-Hyeon Bae, Ho Sun Kim, No Hyeon Kim, Kyu Jin Yang, Gi Bum Lee, In Hyuk Ha   +8 more
openalex   +1 more source

Identification and Validation of Circadian Rhythm‐Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning

JOR SPINE, Volume 8, Issue 2, June 2025.
Within this manuscript, bioinformatics and experimental methods are used to explore the role of circadian rhythm and immunity in Intervertebral Disc Degeneration (IVDD). CCND1, FOXO1, FRMD8, NTRK2, PRRT1, and TFPI were successfully demonstrated to be hub rhythm‐related genes in the process of IVDD together with immunity.
Yongbo Zhang, Liuyang Chen, Sheng Yang, Rui Dai, Hua Sun, Liang Zhang   +5 more
wiley   +1 more source

Síndrome de la cauda equina, caso clínico radiológico

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019
El síndrome de la cauda equina es una emergencia quirúrgica de la columna lumbar, que se caracteriza por un conglomerado de síntomas y signos que incluye el dolor lumbar con ciática, trastornos disfuncionales de la micción, la defecación, el ...
Alexander Sosa-Frias, Leonides Pernia-Plana, Juan Alfredo Campusano-Peña   +2 more
doaj  

Intervertebral disc internal deformation measured by displacements under applied loading with MRI at 3T [PDF]

, 2013
Deva D. Chan, Corey P. Neu
openalex   +1 more source