Results 41 to 50 of about 277,396 (219)

A novel rat model of lumbar disc herniation induced by puncture: accurate positioning and controllable degree of herniation

Journal of Orthopaedic Surgery and Research
Background Lumbar disc herniation (LDH) is the serious stage of intervertebral disc degeneration (IDD), and the location and degree of intervertebral disc herniation are closely related to clinical symptoms and signs.
Ming Yang, Jiangling Zhou, Qiandong Yang, Bo Yu, Juan Cai, Tianyong Hou   +5 more
doaj   +1 more source

Awareness of disc herniation among general population in Aseer province, Saudi Arabia

Journal of Family Medicine and Primary Care, 2019
Background: Herniated lumbar disc is a depositions of discs material (nucleus pulposus and annulus fibrosus) behind the intervertebral disk. Intervertebral disc connected the vertebral bodies together by pad of fibrocartilage.
Abdullah Khalid Alshehri, Turki Khalid Alshehri, Sultan Abdulrahman Alyali, Abdulrahman Abdulelah Alshahrani, Shaker H Alshehri   +4 more
doaj   +1 more source

Sequestered disc herniation mimicking psoas abscess: A rare case report

Radiology Case Reports, 2022
Intervertebral disc herniation is common condition, with majority occurring in lumbar and cervical spine. Most lumbar disk herniations occur within the spinal canal, with approximately 7%-10% identified within the foramen or extraforaminal location ...
Gaurav Parmar, MD, Priti Soin, MD, Pranav Sharma, MD, Christy French, MD, Bing Han, MD, Puneet S. Kochar, MD   +5 more
doaj   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Lumbar disc herniation in ochronosis

Indian Spine Journal, 2019
Alkaptonuria is a rare metabolic, autosomal recessive disorder caused by the deficiency of homogentisic acid oxidase and it is characterized by bluish-black discoloration of cartilages, skin (Ochronosis), degenerative changes in the articular, extra ...
Subbiah Jayakumar, Sathish Devadoss, Annamalai Devadoss   +2 more
doaj   +1 more source

Canadian evidence‐based guidelines on spinal procedures for chronic pain

Anaesthesia, EarlyView.
Summary Introduction Interventional procedures are commonly used to diagnose and treat chronic pain of spinal origin but guidance on: their indications; frequency; technical conduct; requirements for image guidance; outcome measurement; and management of complications is lacking.
Anuj Bhatia, Philip Peng, Harsha Shanthanna, Yasmine Hoydonckx, James S. Khan, Elad Dana, Abeer Alomari, Tarvit Worravitudomsuk, Howard Meng, Martina Rekatsina, Ian Gilron, Andrea D. Furlan, Norman Buckley, Ian Beauprie, Roderick Finlayson, Paul Etheridge, Eldon Loh, Christopher Mares, Mohan Radhakrishna, Sebastian Mafeld, John X. Pereira, Hance Clarke, Shawn Marshall, Magali Robert, Pam Squire, Robert Tanguay, Danielle Alvares   +26 more
wiley   +1 more source

Long‐term follow‐up and post‐operative computed tomography surveillance following adrenalectomy in dogs

Australian Veterinary Journal, EarlyView.
Adrenal gland tumours in dogs have historically been associated with a guarded prognosis due to reported high perioperative mortality, recurrence and metastatic disease. More recent studies suggest improved outcomes following adrenalectomy. This retrospective study evaluated long‐term outcomes and postoperative computed tomography (CT) findings in dogs
TR Nash, GL Hosgood
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source