Results 91 to 100 of about 68,127 (346)

Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. [PDF]

, 2019
Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies.
Dolor, Aaron, Fields, Aaron J, Lazar, Ann A, Lotz, Jeffrey C, Sampson, Sara L, Szoka, Francis C   +5 more
core   +2 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Anesthetic and analgesic management of a skunk (Mephitis mephitis) undergoing a laminectomy for cauda equina compression [PDF]

, 2010
A 6-year-old, male striped skunk (Mephitis mephitis) weighing 5.9 kg was anesthetized for diagnostic imaging procedures and subsequently for a laminectomy at level L6/S1 as treatment of lumbosacral stenosis. On both occasions, anesthesia was induced by a
Gozalo Marcilla, Miguel, Bosmans, Tim, Hellebuyck, Tom, De Decker, Steven, Van Caelenberg, Annemie, Schauvliege, Stijn   +5 more
core  

Development of multiparametric bioprinting method for generation of 3D printed cell‐laden structures

Biotechnology Progress, EarlyView.
Abstract The organ transplantation field requires new approaches for replacing and regenerating tissues due to the lack of adequate transplant methods. Three‐dimensional (3D) extrusion‐based bioprinting is a rapid prototyping approach that can engineer 3D scaffolds for tissue regeneration applications. In this process, 3D printed cell‐based constructs,
Sophie Lipshutz, Yoontae Kim, Micaila Curtis, Leanne Friedrich, Stella Alimperti   +4 more
wiley   +1 more source

IVD-Net: Intervertebral disc localization and segmentation in MRI with a multi-modal UNet [PDF]

arXiv, 2018
Accurate localization and segmentation of intervertebral disc (IVD) is crucial for the assessment of spine disease diagnosis. Despite the technological advances in medical imaging, IVD localization and segmentation are still manually performed, which is time-consuming and prone to errors.
arxiv  

Expression and Localization of aquaporin‐1 in Temporomandibular Joint Disc with Internal Derangement [PDF]

, 2012
Background: Internal derangement is the most frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction.
Almeida, Luis Eduardo, Caltabiano, Rosario, Carnazza, Maria Luisa, Galanti, Concetta, Leonardi, Rosalia, Loreto, Carla, Musumeci, Giuseppe, Pannone, Giuseppe   +7 more
core   +2 more sources

Pharmacokinetics, Safety, and Tolerability of Single‐Dose Dazukibart in Healthy Adults in China and Japan: Results From 2 Randomized, Double‐Blind, Phase 1 Studies

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dazukibart is a humanized monoclonal antibody selectively targeting interferon‐β. The pharmacokinetics (PK), safety, tolerability, and immunogenicity of dazukibart were evaluated in 2 double‐blind, randomized, placebo‐controlled, single‐dose, Phase 1 studies in healthy adults in China (Study 1: N = 18; dazukibart 900 mg = 15; placebo = 3) and ...
Naihan Chen, Yamato Sano, Xiaohong Wang, Shuiyi Hu, Junichi Tabira, Xin Luo, Hiroki Yoshimatsu, John Prybylski, Myron Chu, Haiyan Li, Kenji Takazawa   +10 more
wiley   +1 more source

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Nature Communications, 2018
Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity.
Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu   +9 more
doaj   +1 more source

SPINEPS -- Automatic Whole Spine Segmentation of T2-weighted MR images using a Two-Phase Approach to Multi-class Semantic and Instance Segmentation [PDF]

Purpose. To present SPINEPS, an open-source deep learning approach for semantic and instance segmentation of 14 spinal structures (ten vertebra substructures, intervertebral discs, spinal cord, spinal canal, and sacrum) in whole body T2w MRI. Methods.
arxiv   +1 more source

Impact of through‐slice gradient optimization for dynamic slice‐wise shimming in the cervico‐thoracic spinal cord

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose This study investigates the effectiveness of through‐slice gradient optimization in dynamic slice‐wise B0 shimming of the cervico‐thoracic spinal cord to enhance signal recovery in gradient‐echo (GRE) EPI sequences commonly used in functional MRI studies. Methods Six volunteers underwent MRI acquisitions with dynamic shim updating (DSU)
Arnaud Breheret, Alexandre D'Astous, Yixin Ma, Jason P. Stockmann, Julien Cohen‐Adad   +4 more
wiley   +1 more source