Results 91 to 100 of about 425,188 (323)

A LONG-TERM OUTCOMES OF LUMBAR DISK ARTHROPLASTY AND LUMBAR INTERBODY FUSION IN SURGICAL TREATMENT OF LUMBAR INTERVERTEBRAL DISK DEGENERATIVE DISEASE: A SYSTEMATIC REVIEW

open access: yesБайкальский медицинский журнал
Relevance. Patients with long-standing discogenic low back pain who do not show clinical improvement after conservative treatment are referred for surgical treatments such as lumbar fusion or total disc arthroplasty.The purpose –– to evaluate the long ...
Ivan A. Stepanov, Vladimir A Beloborodov
doaj   +1 more source

Cell Therapy with Human Dermal Fibroblasts Enhances Intervertebral Disk Repair and Decreases Inflammation in the Rabbit Model

open access: yesGlobal Spine Journal, 2016
Study Design Pilot study using the rabbit model. Objective Low back pain is often associated with disk degeneration. Cell therapy for degenerating disks may promote tissue regeneration and repair.
A. Chee   +8 more
semanticscholar   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

open access: yesBMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan   +12 more
wiley   +1 more source

EVALUATION OF MAGNETIC RESONANCE IMAGING GUIDELINES FOR DIFFERENTIATION BETWEEN THORACOLUMBAR INTERVERTEBRAL DISK EXTRUSIONS AND INTERVERTEBRAL DISK PROTRUSIONS IN DOGS.

open access: yesVeterinary Radiology & Ultrasound, 2016
Four MRI variables have recently been suggested to be independently associated with a diagnosis of thoracolumbar intervertebral disk extrusion or protrusion.
S. De Decker   +9 more
semanticscholar   +1 more source

Knockdown of asporin affects transforming growth factor-β1-induced matrix synthesis in human intervertebral annulus cells

open access: yesJournal of Orthopaedic Translation, 2016
Background/Objective: Asporin is associated with osteoarthritis and lumbar disk degeneration. Previous studies in chondrocytes showed that asporin can bind to transforming growth factor-β1 (TGF-β1) and downregulate matrix biosynthesis.
Xu Jiang   +6 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

open access: yesExploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li   +6 more
wiley   +1 more source

Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study

open access: yesJOR Spine, 2018
Mechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of
Steven V. Beekmans   +3 more
doaj   +1 more source

A review of percutaneous techniques for low back pain and neuralgia: current trends in epidural infiltrations, intervertebral disk and facet joint therapies.

open access: yesBritish Journal of Radiology, 2016
Low back pain and neuralgia due to spinal pathology are very common symptoms debilitating numerous patients with peak prevalence at ages between 45 and 60 years. Intervertebral discs and facet joints act as pain sources in the vast majority of the cases.
D. Filippiadis, A. Kelekis
semanticscholar   +1 more source

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