Results 151 to 160 of about 1,511,334 (265)

CAMI: A Counselor Agent Supporting Motivational Interviewing through State Inference and Topic Exploration [PDF]

Yizhe Yang, Palakorn Achananuparp, Heyan Huang, Jing Jiang, Kuangdai Leng, Nicholas K. Lim, Cameron Tan Shi Ern, Ee‐Peng Lim   +7 more
openalex   +1 more source

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Research on the perspectives of people affected by dementia with Lewy bodies: a scoping review. [PDF]

Alzheimers Res Ther
Donnelly PS, Sweeney A, Passmore AP, McCorry NK, Kane JPM.   +4 more
europepmc   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

Advanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang, Zhenyu Guo, Linjie Chen, Jing Sun, Kenny Yat Hong Kwan, Morgan Jones, Yan Michael Li, Yangyang Hu, Xueqiang Wang, Pooyan Makvandi, Xiangyang Wang, Qiuping Qian, Yunlong Zhou, Aimin Wu   +13 more
wiley   +1 more source

"Being empathetic, being accommodating, not only to the person you're talking to, but also to yourself"- a qualitative study on preparing and conducting interviews with palliative care patients. [PDF]

BMC Palliat Care
Giehl C, Suslow A, Vollmar HC, Chikhradze N, Otte IC.   +4 more
europepmc   +1 more source

A topic among others—examining the attention dynamics of the COVID-19 pandemic through interviews with Finnish journalists

, 2022
Timo Harjuniemi
openalex   +1 more source

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury

Advanced Science, EarlyView.
Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang, Shuang Shi, Shuo Liu, Yaqiong Jiao, Bin Huang, Yinghong Yang, Li Yang, Xinquan Yang, Hui Wang, Chunhui Liang, Dandan Song, Huaxiang Yu, Dan Zou, Qi Sun, Shu Yang, Chengqian Yin, Jian Li, Yiming Liu, Junxia Min, Fudi Wang, Yong Nian, Lutao Du, Bo Chu   +22 more
wiley   +1 more source

Lived experiences of patients using positive airway pressure (PAP) therapy: a nested phenomenological study within the 3DPiPPIn randomised controlled trial. [PDF]

BMJ Open
Mansell SK, Gowing F, Hilton ST, Main E, Mandal S, Schievano S, Kilbride C.   +6 more
europepmc   +1 more source

Holleriths Vermächtnis – ein Beitrag zur Geschichte von Frauen in der EDV. Topic Modeling als Methode digitaler Sekundäranalyse lebensgeschichtlicher Interviews

, 2022
Dennis Möbus
openalex   +1 more source