Results 51 to 60 of about 186,734 (260)

Providing medicines-related support for people with COPD before and after hospital discharge—a qualitative study of hospital staff perspectives

BMC Health Services Research
Background People with chronic obstructive pulmonary disease (COPD) are frequently admitted to hospital and experience challenges with their medicines.
Torbjørn Nygård, David Wright, Reidun L. S. Kjome, Hamde Nazar, Aase Raddum   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Motivaciones y actitudes hacia la donación voluntaria de ovocitos: Experiencia de la Unidad de Medicina Reproductiva de la Clínica Monteblanco

Revista Chilena de Obstetricia y Ginecología, 2012
Objetivos: Determinar las motivaciones de mujeres para donar óvulos, y las significaciones que le otorgan a la misma. Método: Entrevista semiestructurada, cualitativa, a 18 mujeres candidatas a donantes de óvulos.
Daniela Solari B, Sonia Villa V, Juan Enrique Schwarze M, José Balmaceda R, Claudia Albornoz G, Ricardo Pommer T   +5 more
doaj  

Development and validation of a novel questionnaire to describe and assess sensations and triggers associated with refractory and unexplained chronic cough

BMJ Open Respiratory Research
Introduction Refractory or unexplained chronic cough (RUCC) is a common clinical problem with no effective diagnostic tools. The Sensations and Triggers Provoking Cough questionnaire (TOPIC) was developed to characterise cough in RUCC versus cough in ...
Janelle Yorke, Shilpi Sen, Jenny King, Jacky Smith, Francesca Solari, Chelsea Sawyer, James Wingfield-Digby, Shannon Galgani, Rachel Dockry, Kimberly Holt, Joanne Mitchell, Danielle Birchall   +11 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Interviewing people on sensitive topics: challenges and strategies

European Journal of Cardiovascular Nursing
Abstract Interviewing participants on sensitive topics is challenging and requires carefully planned and executed strategies throughout the research process. Sensitive topics have the potential to cause distress to participants or researchers.
Heleen Westland, Sigrid Vervoort, Marijke Kars, Tiny Jaarsma   +3 more
openaire   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A movimentação tópica numa visão pragmático discursiva

Cadernos de Estudos Lingüísticos, 2011
This paper retakes previous works on the topic and its development (Aquino, 1991; Fávero, 1993), the relevance of questions and answers in the discursive organization (Fávero, Andrade and Aquino, 1996; Fávero and Andrade, 1998; Fávero and Aquino, 1998 ...
Leonor Lopes Fávero, Maria Lúcia da Cunha Victório Oliveira Andrade, Zilda Gaspar Oliveira de Aquino   +2 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source