Results 71 to 80 of about 1,173,956 (315)

Choosing and using methodological search filters : searchers' views [PDF]

, 2015
© 2014 The authors.
Beale, Sophie, Boachie, Charles, Duffy, Steven, Fraser, Cynthia, Glanville, Julie, Harbour, Jenny, Lefebvre, Carol, McCool, Rachael, Smith, Lynne, Varley, Danielle, Wright, Dianne   +10 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

The Impact of Digitalization in the HR Department: A Post-Pandemic Qualitative Analysis [PDF]

Ovidius University Annals: Economic Sciences Series, 2022
The impact digitalization has on organizations has been a topic of interest for many years and will continue to be due to its complexity. As long as digitalization evolves, so will organizations, and there will always be new areas to uncover.
Oana-Cristina Datcu, Laurențiu-Mihai Tănase, Norina Popovici   +2 more
doaj  

The influence of the visual elements of cover design on the appeal of art and cultural magazines: case study is book fare in Oulu [PDF]

, 2015
Design of magazines - a complex and time-consuming process, often requiring custom solutions. Developers need to know what impact on the visual component of information influence on the audience.
Dubovskaia, Iana
core  

Upper-division Student Understanding of Coulomb's Law: Difficulties with Continuous Charge Distributions

, 2012
Utilizing the integral expression of Coulomb's Law to determine the electric potential from a continuous charge distribution is a canonical exercise in Electricity and Magnetism (E&M).
Caballero, Marcos D., Pepper, Rachel E., Pollock, Steven J., Wilcox, Bethany R.   +3 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Understanding the physical, social, and emotional experiences of people with uncontrolled Type 2 diabetes: a qualitative study

Patient Preference and Adherence, 2016
Anna Berenguera,1,2,* Àngels Molló-Inesta,1,3,4,* Manel Mata-Cases,1,4–6 Josep Franch-Nadal,1,2,6–8 Bonaventura Bolíbar,1 Esther Rubinat,1,9,10 Dídac Mauricio1,11 1Scientific Department, Institut Universitari d ...
Berenguera A, Molló-Inesta À, Mata-Cases M, Franch-Nadal J, Bolíbar B, Rubinat E, Mauricio D   +6 more
doaj  

Examining the contributions of automatic speech transcriptions and metadata sources for searching spontaneous conversational speech [PDF]

, 2007
The searching spontaneous speech can be enhanced by combining automatic speech transcriptions with semantically related metadata. An important question is what can be expected from search of such transcriptions and different sources of related metadata
Jones, Gareth J.F., Lam-Adesina, Adenike M., Newman, Eamonn, Zhang, Ke   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source