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Advanced Healthcare Materials, EarlyView.Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk +6 more
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Food Chemistry, 2015
The interactions occurring at the intestinal level between the fat-soluble vitamins A, D, E and K (FSVs) are poorly documented. We first determined each FSV absorption profile along the duodenal-colonic axis of mouse intestine to clarify their respective absorption sites.
Goncalves, Aurélie +6 more
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The interactions occurring at the intestinal level between the fat-soluble vitamins A, D, E and K (FSVs) are poorly documented. We first determined each FSV absorption profile along the duodenal-colonic axis of mouse intestine to clarify their respective absorption sites.
Goncalves, Aurélie +6 more
openaire +4 more sources
Advances in cell-based permeability assays to screen drugs for intestinal absorption
Expert Opinion on Drug Discovery, 2020Introduction: Successful oral therapy requires sufficient intestinal absorption to enable the drug to reach its site of action. Evaluation of intestinal permeability is important for candidate selection during drug discovery and development.
D. Volpe
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Protoplasma, 1967
Divergent views on the mechanism of fat absorption that prevailed during the past 100 years have recently narrowed to a concept in which most investigators concur. This subject has been recently reviewed (Johnston 1963, Clement 1964, Senior 1964). The distinct (phases of the digestion and absorption of fats will be discussed in the following sections.
J M, Johnston, G A, Rao
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Divergent views on the mechanism of fat absorption that prevailed during the past 100 years have recently narrowed to a concept in which most investigators concur. This subject has been recently reviewed (Johnston 1963, Clement 1964, Senior 1964). The distinct (phases of the digestion and absorption of fats will be discussed in the following sections.
J M, Johnston, G A, Rao
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Molecular Pharmaceutics, 2019
The oral absorption of exenatide, a drug for type 2 diabetes treatment, can be improved by using nanoparticles (NPs) for its delivery. To improve the mucus penetration and intestinal absorption of exenatide, we designed a block copolymer, CSKSSDYQC ...
Yina Song +11 more
semanticscholar +1 more source
The oral absorption of exenatide, a drug for type 2 diabetes treatment, can be improved by using nanoparticles (NPs) for its delivery. To improve the mucus penetration and intestinal absorption of exenatide, we designed a block copolymer, CSKSSDYQC ...
Yina Song +11 more
semanticscholar +1 more source
Intestinal absorption of galactose
Biochimica et Biophysica Acta, 1960Abstract Galactose absorption from the rat intestine was studied in the intact animal, in the perfused intestine and in the isolated intestinal loop. In the intact animal an average porto-arterial difference of 16.1 milligram per cent galactose was found. At the same time there was no porto-arterial difference in the total reducing sugar.
R, TZUR, B, SHAPIRO
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Comprehensive Physiology, 2021
AbstractIn this article, we focus on mammalian calcium absorption across the intestinal epithelium in normal physiology. Intestinal calcium transport is essential for supplying calcium for metabolism and bone mineralization. Dietary calcium is transported across the mucosal epithelia via saturable transcellular and nonsaturable paracellular pathways ...
Kannikar, Wongdee +3 more
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AbstractIn this article, we focus on mammalian calcium absorption across the intestinal epithelium in normal physiology. Intestinal calcium transport is essential for supplying calcium for metabolism and bone mineralization. Dietary calcium is transported across the mucosal epithelia via saturable transcellular and nonsaturable paracellular pathways ...
Kannikar, Wongdee +3 more
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Intestinal cholesterol absorption
Current Opinion in Lipidology, 1999The strong association between intestinal cholesterol absorption and total plasma cholesterol level has renewed interest in the absorptive process and stimulated the generation of new animal models. Increasingly, new studies suggest that cholesterol absorption is genetically controlled and supports a protein-mediated mechanism for cholesterol uptake ...
P A, Dawson, L L, Rudel
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Intestinal absorption of heparin
Canadian Journal of Biochemistry, 1969Dimethylsulfoxide and diethylsulfone, and their homologues, induced the absorption of heparin from the rabbit intestine.Using the criterion of prolongation of whole blood clotting time, it was found that the quantitative absorption of heparin, as induced by di-n-propylsulfoxide or di-n-propylsulfone, increased with increasing amount of sodium ...
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