Results 31 to 40 of about 2,592,772 (309)

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Global burden of malaria before and after the COVID-19 pandemic based on the global burden of disease study 2021

Scientific Reports
Malaria poses significant public health challenges and huge disease and economic burdens across the world, notably in low-income countries. Although great strides have been achieved, the COVID-19 pandemic hinders the progress towards global elimination ...
Jiaofeng Huang, Yuekai Hu, Yinlian Wu, Li Pan, Mingfang Wang, Wei Wang, Su Lin   +6 more
doaj   +1 more source

“Smelltronics”—From Gas to Smell Sensing

Advanced Materials, EarlyView.
The emerging field of smelltronics, encompassing sensing technologies for complex volatile organic compounds, holds significant potential for extracting valuable chemical information. It facilitates the noninvasive, real‐time monitoring of humans, food, and the environment.
Takeshi Ono, Tsunaki Takahashi, Jiangyang Liu, Haruka Honda, Zeng Jing, Wataru Tanaka, Takuro Hosomi, Takeshi Yanagida   +7 more
wiley   +1 more source

Predictors of Intestinal Parasitic Infection among Food Handlers Working in Madda Walabu University, Ethiopia: A Cross-Sectional Study

Interdisciplinary Perspectives on Infectious Diseases, 2020
Background. Intestinal parasitic infection is one of the major health problems globally. It is more common in developing countries including Ethiopia. So, adequate evidence is needed regarding the predictors of intestinal parasitic infection.
Kemal Ahmed Kuti, Rameto Aman Nur, Geroma Morka Donka, Amene Abebe Kerbo, Adem Esmael Roba   +4 more
doaj   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Prevalence Of Intestinal Parasites In The Elderly Enrolled In The Family Health Strategy In Porto Alegre, Brazil [PDF]

Geriatrics, Gerontology and Aging
OBJECTIVE: There are few studies on intestinal parasitic infections in elderly populations. Therefore, this study aimed to determine the prevalence of intestinal parasites and identify the association between this prevalence and the sociodemographic ...
Paula Engroff, Luísa Scheer Ely, Aline Bueno da Silva, Karin Viegas, Fernanda Loureiro, Irenio Gomes, Geraldo Attilio DeCarli   +6 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Intestinal parasitic infections and associated factors among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis.

PLoS ONE, 2020
BackgroundIntestinal parasitic infections are major public health problems throughout the world, particularly in people living with HIV/AIDS. People living with HIV/AIDS are vulnerable groups for a variety of diseases, hence they are easily affected by ...
Adam Wondmieneh, Getnet Gedefaw, Birhan Alemnew, Addisu Getie, Melaku Bimerew, Asmamaw Demis   +5 more
doaj   +1 more source

Planning, implementation, monitoring and evaluation of the control of intestinal parasitic infections (IPI programmes [PDF]

, 1985
ONLINEPDP/85.3.
World Health Organization. Parasitic Diseases Programme
core  

Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections [PDF]

, 2016
Treatment options for infections with soil-transmitted helminths (STH) - Ascaris lumbricoides, Trichuris trichiura and the two hookworm species, Ancylostoma duodenale and Necator americanus - are limited despite their considerable global health burden ...
Ivan Scandale (349072), Jennifer Keiser, Mireille Vargas (392661), Ivan Scandale, Noemi Cowan, Adelfio, Roberto, Panic, Gordana, Gordana Panic, Roberto Adelfio, Cowan, Noemi, Gordana Panic (507685), Roberto Adelfio (392660), Keiser, Jennifer, Scandale, Ivan, Jennifer Keiser (39606), Vargas, Mireille, Noemi Cowan (507684), Mireille Vargas   +17 more
core   +1 more source