Results 151 to 160 of about 874,138 (343)

Advanced Parkinson’s Disease Treatment Simplification and Long-Term Outcomes with Levodopa Carbidopa Intestinal Gel: COSMOS Romanian Subanalysis [PDF]

, 2021
Mihaela Simu, Dragoş Cătălin Jianu, Adriana Octaviana Dulămea, Viorelia Constantin, Diana Popescu, Juan Carlos Parra, József Attila Szász   +6 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Prognosticating post-bariatric surgery outcomes and management of postoperative recurrent weight gain and diabetes recurrence

Frontiers in Nutrition
Bariatric surgery stands as the most potent treatment for achieving substantial weight reduction and alleviating the complications associated with obesity. However, it is not the treatment of choice for patients with obesity combined with type 2 diabetes
He Xiao, He Xiao, Yudie Du, Yudie Du, Yuanyuan Tan, Yuanyuan Tan, Yixing Ren, Yixing Ren, Yixing Ren   +8 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

P063 The immunological landscape of intestinal fibrosis in Crohn’s Disease [PDF]

, 2021
Inge Jacobs, Brecht Creyns, Gabriele Dragoni, Jonathan Cremer, Gabriele Bislenghi, André D’Hoore, B J Ke, Gianluca Matteoli, Gert De Hertogh, Marc Ferrante, G S Joao, Christine Breynaert, Séverine Vermeire, Bram Verstockt, Tim Vanuytsel   +14 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Long-term disease control of monomorphic epitheliotrophic intestinal T-cell lymphoma (MEITL) with CNS involvement in a caucasian patient by allogeneic hematopoietic cell transplantation [PDF]

Markus Lindauer, Florian Reissfelder, Ute Hegenbart, Thomas Luft, Uwe M. Martens, Peter Dreger   +5 more
openalex   +1 more source

Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease [PDF]

, 2012
Stijn J.B. Van Weyenberg, Koen Bouman, Maarten Jacobs, Brendan P. Halloran, Donald L. van der Peet, Chris J. Mulder, Cornelis van Kuijk, J.H.T.M. van Waesberghe   +7 more
openalex   +1 more source

Natural dairy cow health [PDF]

, 2011
guide to keeping your herd healthy with herbs and other natural ...
Groot, Maria, Hansma, Hanneke, Kleijer-Ligtenberg, Gerdien, van Asseldonk, Tedje   +3 more
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