Results 131 to 140 of about 3,100,266 (306)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Primary suture of anastomotic leakage following Altemeier procedure: A case report

Asian Journal of Surgery, 2023
Xiang Zhai, Baoxiang Chen, Xianghai Ren, Congqing Jiang   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Sleeve gastrectomy ameliorates renal injury in obesity-combined hyperuricemic nephropathy mice by modulating the AMPK/Nrf2/ABCG2 pathway

Scientific Reports
Hyperuricemic nephropathy (HN) is renal injury caused by hyperuricemia (HUA). While sleeve gastrectomy (SG) has shown promise in improving renal injury in patients with obesity-related HN, the mechanisms are not fully understood.
Ke Song, Xiangxin Kong, Zhongyang Zhang, Yin Xian, Ming He, Yuan Zhang, Xinxin Liao, Ziyan Huang, Aijia Kang, Dingqi Xiao, Yixing Ren   +10 more
doaj   +1 more source

Arthritis and Intestinal Disease

Journal of the Royal College of Physicians of London, 1974
I, Haslock, V, Wright
openaire   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model

Immunity, Inflammation and Disease
Introduction Regulatory T cells (Tregs) play an important role in inflammatory bowel diseases (IBDs) through modulating intestinal inflammation. However, the factors affecting Treg function and plasticity during IBD progression are not thoroughly ...
Liuqing Ge, Min Xu, Meifang Huang, Shaoping Liu, Zhidai Zhou, Ziqin Xia, Qiu Zhao, Feng Zhou   +7 more
doaj   +1 more source

Esophageal submucosal gland duct adenoma: a case report and pooled analysis of demographic differences between eastern and western populations

Frontiers in Oncology
BackgroundEsophageal submucosal gland duct adenoma (ESGDA) is an exceptionally rare benign tumor. Classic teaching suggests a predilection for the upper and mid esophagus.
Yuhua Chen, Yuhua Chen, Yafei Zhang, Yafei Zhang, Liuqing Ge, Liuqing Ge   +5 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

To explore the postoperative nutritional status and factors influencing prognosis in patients with chronic constipation complicated by malnutrition

Frontiers in Medicine
BackgroundMany patients with constipation also suffer from varying degrees of malnutrition, and the relationship between the two conditions is a vicious cycle.
Le Wang, Le Wang, Hongliang Tian, Hongliang Tian, Hongliang Tian, Long Li, Long Li, Chen Ye, Chen Ye, Jiaqu Cui, Jiaqu Cui, Zhiliang Lin, Zhiliang Lin, Bo Yang, Bo Yang, Di Zhao, Di Zhao, Ning Li, Ning Li, Xiaobo Feng, Qiyi Chen, Qiyi Chen, Qiyi Chen   +22 more
doaj   +1 more source