Results 181 to 190 of about 5,424,793 (311)

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Mitigation of oxidative stress in chicken intestinal epithelial cells by functional nutrients. [PDF]

J Anim Sci Technol
Lee SY, Jang HG, Lee HW, Kim DB, Lee HJ, Park JH, Lee HN, Yeom GL, Park JY, Kim YB, Kim JH.   +10 more
europepmc   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

PACSIN2 regulates mercaptopurine cytotoxicity and cellular biomechanics through Rac1 modulation in intestinal epithelial cells. [PDF]

Front Pharmacol
Norbedo A, Zudeh G, Fiducioso D, Senigagliesi B, Parisse P, Casalis L, Decorti G, Lucafò M, Stocco G.   +8 more
europepmc   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Dietary Antigen Interaction with Intestinal Epithelial Cells. [PDF]

Curr Allergy Asthma Rep
Reichel PE, Chakraborty S, Tay HL, Hogan SP.   +3 more
europepmc   +1 more source

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

Advanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang, Songming Zhang, Xiaofeng Chen, Xiongtao Xiao, Wenming Cao, Weikai Li, Tong Zhao, Bing Li, Xinyue Xu, Zhongshan Li   +9 more
wiley   +1 more source

RUNX2 promotes chromatin accessibility and WNT signaling in inflamed intestinal epithelial cells. [PDF]

Mucosal Immunol
Cabrera-Silva RI, Wilson ZS, Miranda J, Fan S, Dame M, Bishu S, Spence JR, Brazil JC, Colacino J, Nusrat A, Parkos CA.   +10 more
europepmc   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Phenolic-Rich Lentil Extracts Regulate Cytokine Production, Metabolic Pathways and Barrier Function in Intestinal Epithelial Cells. [PDF]

Mol Nutr Food Res
Geraldo R, Machado M, Costa E, Pinho S, Gouveia A, Neves D, Freitas V, Pinto E, Pintado M, Vasconcelos MW.   +9 more
europepmc   +1 more source