Results 101 to 110 of about 2,055,082 (206)

Use of vedolizumab in pediatric intestinal transplant rejection

Intestinal Failure
Background: Blockade of α4β7 integrin cell adhesion receptors on activated lymphocytes with the monoclonal antibody vedolizumab (VDZ) is efficacious in treatment of inflammatory bowel disease and most probably intestinal graft versus host disease (GVHD ...
Shahira Ghobrial, Dimitrios Moris, Carolina Rumbo, Stuart S. Kaufman, Gabriel Gondolesi, Dong Hyang Kwon, Yoshinori Takeda, Nada Yazigi, Udeme D. Ekong, Thomas M. Fishbein, Cal S. Matsumoto, Alexander Kroemer, Khalid Khan   +12 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Cost-effectiveness of intestinal transplantation for adult patients with intestinal failure: a simulation study

, 2015
Background: Home parenteral nutrition (HPN) and intestinal transplantation (ITx) are the 2 treatment options for irreversible intestinal failure (IF). Objective: This study simulated the disease course of irreversible IF and both of these treatments HPN ...
Haveman, Jan Willem, Gerard Dijkstra, Krabbe, Paul F. M.; id_orcid, Dijkstra, Gerard, Roskott, Anne Margot, Rings, Edmond H. H. M., Rutger J Ploeg, Edmond Hhm Rings, Mireille J Serlie, Dijkstra, Gerard; id_orcid, Groen, Henk; id_orcid, Jan Willem Haveman, Geert Wanten, Krabbe, Paul F. M., Wanten, Geert, Groen, Henk, Anne Margot Roskott, Paul Fm Krabbe, Serlie, Mireille J., Henk Groen, Ploeg, Rutger J.   +20 more
core   +1 more source

A rare case of non-oncologic metastasis: Keep calm and check the veins

Intestinal Failure
We report the case of a 57-year-old patient with short bowel syndrome and chronic intestinal failure secondary to multiple resections for Crohn’s disease, requiring parenteral nutrition (PN) since 1997.
Imane Habbal, Francisca Joly, Raphael Bacquet, Eric Le Bihan, Flore de Castelbajac   +4 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Proof of principle study for the development of the world’s smallest long-term short bowel syndrome pig model using microminipigs

Intestinal Failure
Background: This study describes the development of a long-term short bowel syndrome (SBS) model that does not require parenteral nutrition (PN) using Microminipigs (MMP), the smallest experimental pigs, with an adult weight of ≤ 30 kg. Methods: Two MMPs
Hironori Kudo, Ryoma Endo, Eiji Kobayashi, Yuto Yamazaki, Motoshi Wada   +4 more
doaj   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Approaches to intestinal failure in Crohn's disease

, 2011
Crohn's disease is one of the leading causes of intestinal failure. The term ‘type 2’ intestinal failure is used to describe the relatively rare type of intestinal failure that occurs in association with septic, metabolic and complex nutritional ...
C. R. Calvert, S. Lal
core   +1 more source

The changing landscape of intestinal transplantation: Insights from the first quarter of the 21st century of Eurotransplant experience

Intestinal Failure
Background: Intestinal transplantation (ITx) remains one of the most complex procedures in solid organ transplantation. This study analyzes 25 years of Eurotransplant data to evaluate trends, outcomes, and prognostic factors.
Mando D. Filipe, Marit Kalisvaart, Manuel Maglione, Axel Jens, Stipislav Jadrijevic, Jan Willem Haveman, Andreas Pascher, Jacques Pirenne   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source