Results 81 to 90 of about 2,055,082 (206)

Gastric bypass reversal in patients with short bowel syndrome

Intestinal Failure
Background: 5–10 % patients developing short bowel syndrome (SBS) have undergone a previous gastric bypass (GBP) for morbid obesity. The benefits of restoring gastric anatomy in these patients is assumed but remains unclear.
Jon S. Thompson, Fedja A. Rochling, Elizabeth Lyden, Shaheed Merani, Luciano Vargas, Wendy J. Grant, Alan N. Langnas, David F. Mercer   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Characteristics and clinical outcomes of pediatric patients following massive bowel resection: A retrospective cohort study

Intestinal Failure
Background: Massive bowel resection (MBR), defined as residual small bowel
Clarelle L. Gonsalves, Christina Belza, Glenda Courtney-Martin, Yaron Avitzur, Jill Quirt, Victoria Srbely, Paul W. Wales   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Perspectives of intestinal rehabilitation providers on the use of oral rehydration solutions for pediatric patients with short bowel syndrome

Intestinal Failure
Background: Patients with short bowel syndrome (SBS) have a loss of absorptive bowel surface area and are at risk for dehydration. Oral rehydration solutions (ORS) promote intestinal fluid absorption and may be used to maintain adequate hydration ...
Juliana Kennedy, Grace Altamura-Murgia, Maryanna Tosi, Kishore Iyer, Joanne Lai   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Assessment and management of patients with intestinal failure: a multidisciplinary approach

, 2018
Jennie T Grainger,1 Yasuko Maeda,1,2 Suzanne C Donnelly,1 Carolynne J Vaizey1,2 1The Lennard Jones Intestinal Failure Unit, St. Mark’s Hospital, Harrow, UK; 2Faculty of Medicine, Imperial College London, London, UK Abstract: Intestinal failure (IF)
Maeda Y, Vaizey CJ, Donnelly SC, Grainger JT   +3 more
core  

Isolated intestinal transplantation for megacystis microcolon intestinal hypoperistalsis syndrome: Case report

, 2014
MMIHS is a rare congenital disease. It is characterized by distended urinary bladder, small colon and intestinal hypoperistalsis, or aperistalsis with normal morphology. There is no specific treatment for MMIHS, and most patients have to be maintained by
曾勝弘, Huang, Chen-Ming;Tseng, Sheng-Hong;Weng, Chia-Chee;Chen, Yun   +1 more
core   +1 more source

Interactions of intestinal epithelial cells with bacterial extracellular products [PDF]

The enteric microflora represents one of the densest microbial populations in the biological world; as a consequence, the intestinal immune system is constantly exposed to high concentrations of antigenic materials. One of the major frontline defences in
Patten, Daniel
core   +3 more sources

A neonatal intensive care nurse experience of an automated chyme reinfusion therapy device: A case report describing use in a neonate with necrotising enterocolitis

Intestinal Failure
Background: Neonatal intestinal failure related to double enterostomies is rare and associated with high morbidity and mortality. Chyme reinfusion therapy (CRT) remediates high outputs and improves nutrition and electrolyte balance of neonates.
Taylor Harrington, Emma Ludlow
doaj   +1 more source