Results 61 to 70 of about 2,055,082 (206)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Modulating the gut microbiota in Crohn’s disease: a pilot study on the impact of a plant-based diet with DNA-based monitoring

Frontiers in Nutrition
IntroductionCrohn’s Disease (CD) is characterized by chronic intestinal inflammation and dysbiosis. This study aimed to investigate the effects of a plant-based diet (PBD) on gut microbiota composition and inflammation in CD patients and assess the ...
Stine Karstenskov Østergaard, Zeynep Cetin, Zeynep Cetin, Henrik Højgaard Rasmussen, Henrik Højgaard Rasmussen, Henrik Højgaard Rasmussen, Helle Nygaard Lærke, Mette Holst, Mette Holst, Charlotte Lauridsen, Charlotte Lauridsen, Jeppe Lund Nielsen   +11 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The National Intestinal Failure and Rehabilitation Service (NIFRS): 10 years of experience in New Zealand

The vast majority of NZ patients with IF who are notified to NIFRS achieve enteral autonomy. Intestinal dysmotility, fistula and mechanical obstruction are the commonest aetiologies in adults, and short bowel, extensive mucosal disease and mechanical ...
Gemmell, Candice, Herbison, Kim, Bissett, Ian, King, Tim, Fraser Irwin, Cate, Roberts, Amin, Andrews, Amy, Evans, Helen, Xia, Andrew   +8 more
core   +1 more source

Human intestinal spirochetes are distinct from Serpulina hyodysenteriae [PDF]

, 1993
Twenty-nine intestinal spirochetes isolated from Australian aboriginal children and six strains from Italian adults (HRM1, -2, -4, -5, -7, and -14) were genetically examined at 15 enzyme loci by using multilocus enzyme electrophoresis.
Lymbery, A.J., Hampson, D.J., McLaren, A.J., Lee, J.I.   +3 more
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Intestinal barrier function and absorption in pigs after waeaning: a review [PDF]

, 2011
Under commercial conditions, weaning of piglets is associated with social, environmental and dietary stress. Consequently, small-intestinal barrier and absorptive functions deteriorate within a short time after weaning.
Wijtten, P.J.A., Verstegen, M.W.A., Meulen, J., van der   +2 more
core   +1 more source

Changes in rat intestinal motility and absorption following intestinal transplantation: an experimental study

Transplant International
Intestinal transplantation (ITx) is a life-saving procedure for patients with complicated intestinal failure. In the acute phase, allograft permeability increases primarily due to ischemia-reperfusion injury. However, long-term allograft physiology after
Antoine Dubois, Antoine Dubois, Antoine Dubois, Amélie Leenders, Gert De Hertogh, Alice Rustichelli, Caroline Boelhouwer, Caroline Boelhouwer, Tine Wylin, Veerle Heedfeld, Eliano Bonaccorsi-Riani, Jacques Pirenne, Jacques Pirenne, Tim Vanuytsel, Tim Vanuytsel, Ricard Farré, Laurens J. Ceulemans, Laurens J. Ceulemans   +17 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Colonic dilation is associated with increased central line associated blood stream infection for patients with intestinal failure

Intestinal Failure
Introduction: Management of intestinal failure involves supplemental nutrition and complication minimization to achieve enteral autonomy. Previous research to identify prognostic factors in IF focused on the small bowel, yet little work has been done to ...
Pamela Emengo, Shweta S. Namjoshi, James C.Y. Dunn   +2 more
doaj   +1 more source