Results 41 to 50 of about 2,055,082 (206)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Assessment of liver stiffness and steatosis in patients with intestinal failure: a cross-sectional study

Frontiers in Nutrition
IntroductionIntestinal failure-associated liver disease is a potentially life-threatening complication in patients with intestinal failure (IF) receiving home parenteral support (HPS).
Ena Muhic, Rahim Mohammad Naimi, Christopher Filtenborg Brandt, Thomas Lund Andersen, Thomas Lund Andersen, Helle Hjorth Johannesen, Palle Bekker Jeppesen   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The study of infectious intestinal disease in England: socio-economic impact [PDF]

, 2003
To assess the socio-economic impact of infectious intestinal disease (IID) on the health care sector, cases and their families, cases of IID ascertained from a population cohort component and those presenting to general practices were sent a socio ...
Rodrigues, L.C., Sockett, PN, Cumberland, P., Rodrigues, LC, Sethi, D., Infectious Intestinal Disease Study Executive, Sockett, P.N., Wheeler, J, Roderick, PJ, Roderick, P.J., Roberts, JA, Wheeler, J., Roberts, J.A., Cumberland, P, Sethi, D   +14 more
core   +1 more source

Alpha1-antitrypsin protects the intestine from ischemia-reperfusion injury in a rat intestinal clamping model

Intestinal Failure
Background: Ischemia-reperfusion injury (IRI) remains a significant hurdle when blood flow is restored to ischemic tissue. Alpha1-antitrypsin (AAT), a serine protease inhibitor, has demonstrated strong anti-inflammatory properties, including inhibition ...
Antoine Dubois, Mathias Clarysse, Ricard Farré, Tine Wylin, Veerle Heetfeld, Emilio Canovai, Tim Vanuytsel, Gert De Hertogh, Jacques Pirenne, Laurens J. Ceulemans   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

NEONATAL ONSET INTESTINAL FAILURE

, 2008
Objective To describe the natural course of intestinal failure with onset in the neonatal period to provide data regarding the occurrence and to provide a population-based survey regarding the spectrum of underlying diseases.
C. Cascioli, F. Indrio, M. Stronati, P. Tagliabue, M. De Curtis, CORVAGLIA, LUIGI TOMMASO, R. Paludetto, G. Terrin, S. Fanaro, G. Salvia, A. Guarino, L. Lega   +11 more
core   +1 more source

Resting energy expenditure is not defined by bowel function among patients with intestinal failure

Clinical Nutrition Open Science
Background & Aims: Resting energy expenditure (REE) is a critical parameter for assessing energy requirements in patients with chronic intestinal failure (CIF). This study aimed to investigate the influence of intestinal functionality, defined by the
Caroline Amalie Krag, Signe Amalie Schaaning Heuckendorff, Alberte Schneevoigt Højrup, Caroline Bang Pedersen, Sabina Mikkelsen, Marianne Køhler, Henrik Højgaard Rasmussen, Mette Holst   +7 more
doaj   +1 more source