Results 71 to 80 of about 2,055,082 (206)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification of a new intestinal spirochete with pathogenicity for chickens [PDF]

, 1995
Two intestinal spirochete isolates obtained from chickens with diarrhea were examined by electron microscopy, biochemical tests, rRNA gene restriction pattern analysis, and multilocus enzyme electrophoresis.
Hampson, D.J., Jensen, N.S., Swayne, D.E, Stoutenburg, J., Trott, D.J., Eaton, K.A.   +5 more
core  

Acute intestinal failure

, 2010
Purpose of review: The review aims to highlight the importance of acute gastrointestinal failure in the postoperative patient, to clarify the clinical circumstances in which acute intestinal failure complicates postoperative management, and to discuss ...
Carlson, Gordon L., Dark, Paul; id_orcid
core   +1 more source

DIARRHEA IN EARLY LIFE: PROGRESS IN DIAGNOSIS AND CONTROL OF DISEASE [PDF]

, 2010
Diarrheal diseases occurring in early life (< 3 years) are an heterogeneous group of abnormalities including gastrointestinal infections, food hypersensitivity and allergy, immune dysregulation, and primary abnormalities of the enterocyte.
Terrin, Gianluca
core   +1 more source

The negative impact on sleep for caregivers of children with intestinal failure on long-term parenteral nutrition

Intestinal Failure
Objectives: Survival rates for children with intestinal failure (IF) have improved with care provided in the home by family caregivers. Our objective was to compare total nocturnal sleep time (TST-N) in caregivers of children with IF on home PN to ...
Christina Belza, Paul W. Wales, Darcy Fehlings, Wendy J. Ungar, Yaron Avitzur, Robyn Stremler   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Intestinal failure in childhood [PDF]

, 2010
Intestinal failure (IF) requires the use of parenteral nutrition (PN) for as long as it persists and in case of irreversible IF may be an indication for intestinal transplantation (ITx).
Goulet, O
core  

Evolution of intestinal and multivisceral transplantation: A thirty-year United States perspective

Intestinal Failure
Background: The field of intestinal transplantation has significantly changed since the report of the first successful transplant in 1988. This report seeks to describe the trends in intestinal transplantation utilization and outcomes over time in the ...
Mariya L. Samoylova, Samuel J. Kesseli, Christine Park, John Yerxa, Simon Horslen, Syed-Mohammed Jafri, Alisha Mavis, Thomas Schiano, Bryant Summers, Andrew S. Barbas, Brian I. Shaw, Debra L. Sudan, M. Cristina Segovia   +12 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Patient- and clinician-reported acute radiation-induced diarrhoea in patients with prostate cancer during curative external radiation therapy: A prospective observational cohort study

Journal of Patient-Reported Outcomes
Background Acute radiation-induced diarrhoea (RID) typically develops from gut mucosa inflammation within 2 weeks of external beam radiation therapy (EBRT) to the pelvis.
Mette Overgaard Holm, Ursula Falkmer, Randi Tobberup, Martin Skovmos Nielsen, Bjarke Mortensen, Rasmus Froberg Brøndum, Christine Vestergård Madsen, Henrik Højgaard Rasmussen, Mette Karen Yilmaz, Jimmi Søndergaard, Mette Moe, Laurids Østergaard Poulsen   +11 more
doaj   +1 more source