Results 151 to 160 of about 670,134 (326)

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Drug discovery via human-derived stem cell organoids

Frontiers in Pharmacology, 2016
Patient-derived cell lines and animal models have proven invaluable for the understanding of human intestinal diseases and for drug development although both inherently comprise disadvantages and caveats.
Fangkun Liu, Fangkun Liu, Jing Huang, Jing Huang, Bo Ning, Zhixiong Liu, Shen Chen, Shen Chen, Wei Zhao, Wei Zhao   +9 more
doaj   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance

Advanced Healthcare Materials, EarlyView.
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli, Marco Gargaro, Giuliana Drava, Valerio Voliani   +3 more
wiley   +1 more source

No causal relationship between serum vitamin D levels and alcoholic liver disease: a two-sample bidirectional Mendelian randomization study

Frontiers in Nutrition
BackgroundNumerous observational studies have presented an association between Vitamin D (VD) and Alcoholic Liver Disease (ALD). However, sufficient evidence from Randomized Controlled Trials (RCTs) substantiating this correlation is scarce, thus leaving
Huan Wu, Long Wu, Quan Zhang, Can Li, Hai-yang Li, Bao-fang Zhang   +5 more
doaj   +1 more source

Increasing prevalence of a fluoroquinolone resistance mutation amongst Campylobacter jejuni isolates from four human infectious intestinal disease studies in the United Kingdom [PDF]

, 2020
Sam Haldenby, Christina Bronowski, Charlotte Nelson, John Kenny, C. Martínez-Rodríguez, Roy R. Chaudhuri, Nicola Williams, Ken J. Forbes, Norval J. C. Strachan, Jane A. Pulman, Ian N. Winstanley, Caroline Corless, T. J. Humphrey, F. J. Bolton, S. O’Brien, Neil Hall, Christiane Hertz‐Fowler, Craig Winstanley   +17 more
openalex   +1 more source

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, EarlyView.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Nanohybrid Hydrogel with Dual Functions: Controlled Low‐Temperature Photothermal Antibacterial Activity and Promoted Regeneration for Treating MRSA‐Infected Bone Defects

Advanced Healthcare Materials, EarlyView.
An injectable polydopamine‐based nanohybrid hydrogel integrates controlled low‐temperature photothermal therapy with potent antibacterial efficacy against MRSA while promoting robust bone regeneration. The hydrogel's composite design triggers HSP70 expression, facilitating osteogenesis and efficient bone formation.
Fang Yang, Zewen Shi, Yiwei Hu, Qian Pang, Tianyu Du, Baiyang Song, Jiaqi Zhong, Xiaodong Hu, Weilai Zhu, Junhong Chen, Lin Shi, Xianjun Chen, Qingjiang Pang, Yabin Zhu   +13 more
wiley   +1 more source

The reachability of contagion in temporal contact networks: how disease latency can exploit the rhythm of human behavior [PDF]

arXiv, 2017
The symptoms of many infectious diseases influence their host to withdraw from social activity limiting their own potential to spread. Successful transmission therefore requires the onset of infectiousness to coincide with a time when its host is socially active.
arxiv  

Advanced Materials for Biological Field‐Effect Transistors (Bio‐FETs) in Precision Healthcare and Biosensing

Advanced Healthcare Materials, EarlyView.
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey, Manish Bhaiyya, Prakash Rewatkar, Jitendra B. Zalke, Nitin P. Narkhede, Hossam Haick   +5 more
wiley   +1 more source