Results 81 to 90 of about 321,806 (308)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Spatial heterogeneity of bacterial colonization across different gut segments following inter-species microbiota transplantation

Microbiome, 2020
Background The microbiota presents a compartmentalized distribution across different gut segments. Hence, the exogenous microbiota from a particular gut segment might only invade its homologous gut location during microbiota transplantation. Feces as the
Na Li, Bin Zuo, Shimeng Huang, Benhua Zeng, Dandan Han, Tiantian Li, Ting Liu, Zhenhua Wu, Hong Wei, Jiangchao Zhao, Junjun Wang   +10 more
doaj   +1 more source

Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health [PDF]

, 2018
Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
Chambers, Edward S., Frost, Gary, Morrison, Douglas J., Preston, Tom   +3 more
core   +1 more source

Impact of Intestinal Microbiota on Intestinal Luminal Metabolome [PDF]

Scientific Reports, 2012
Low-molecular-weight metabolites produced by intestinal microbiota play a direct role in health and disease. In this study, we analyzed the colonic luminal metabolome using capillary electrophoresis mass spectrometry with time-of-flight (CE-TOFMS) -a novel technique for analyzing and differentially displaying metabolic profiles- in order to clarify the
Matsumoto, Mitsuharu, Kibe, Ryoko, Ooga, Takushi, Aiba, Yuji, Kurihara, Shin, Sawaki, Emiko, Koga, Yasuhiro, Benno, Yoshimi   +7 more
openaire   +2 more sources

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]

, 2016
Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core   +1 more source

Digestive disorders and Intestinal microbiota.

Acta bio-medica : Atenei Parmensis, 2018
In the last decade, a barge body of scientific literature has suggested that specific alterations of the gut microbiota may be associated with ther development and clinical course of several gastrointestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, celiac disease, gastrointestinal cancer and Clostridium difficile ...
Nouvenne, Antonio, Ticinesi, Andrea, Tana, Claudio, Prati, Beatrice, Catania, Pamela, Miraglia, Chiara, De' Angelis, Gian Luigi, Di Mario, Francesco, Meschi, Tiziana   +8 more
openaire   +4 more sources

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Microbiota signatures in type-2 diabetic patients with chronic kidney disease - A Pilot Study [PDF]

, 2019
The human microbiota is paramount for normal host physiology. Altered host-microbiome interactions are part of the pathogenesis of numerous common ailments.
Chifiriuc, Mariana Carmen, Gradisteanu, Gratiela P., Petcu, Laura, Picu, Ariana, Salmen, Teodor, Serafinceanu, Cristian, Stefan, Diana S., Stoian, Anca P., Stoica, Roxana A., Suceveanu, Adrian P.   +9 more
core   +1 more source

Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients. [PDF]

, 2015
Differences in the gut microbiota have been reported between individuals with autism spectrum disorders (ASD) and neurotypical controls, although direct evidence that changes in the microbiome contribute to causing ASD has been scarce to date.
Debelius, Justine, Gilbert, Jack A, Hornig, Mady, Knight, Rob, Lozupone, Catherine, McDonald, Daniel   +5 more
core   +3 more sources